KEY RESOURCES TABLE

REAGENT or RESOURCE	SOURCE	IDENTIFIER
Deposited Data
Whole exome sequencing data of 52 VOGM trios and 3 singletons	This paper	Accession no. phs000744.v4.p2  http://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs000744
Whole exome sequencing data of 1,789 control trios from the Simon Simplex Collection	Iossifov et al., 2014	NDAR: DOI:10.15154/1149697 https://ndar.nih.gov/study.html?id=352
Software and Algorithms
Genome Analysis Tool Kit (GATK)	DePristo et al., 2011; McKenna et al., 2010; Van der Auwera et al., 2013	https://software.broadinstitute.org/gatk/best-practices/
BWA-mem	Li and Durbin, 2009	http://bio-bwa.sourceforge.net/
Annovar	Wang et al., 2010	http://annovar.openbioinformatics.org/en/latest/
PLINK/SEQ	Fromer et al., 2014	https://atgu.mgh.harvard.edu/plinkseq/
Antibodies
Anti-HA-Tag antibody	Cell Signaling Technology, Danvers, MA, USA	AB_10691311
Other
1000 Genomes GRCh37 h19 genome build	1000 Genomes Project	http://ftp.1000genomes.ebi.ac.uk/vol1/ftp/technical/reference/human_g1k_v37.fasta.gz
RefSeq hg19 gene annotation	UCSC Genome Browser	http://genome.ucsc.edu/cgi-bin/hgTables?command=start
Intervals file for IDT xGen v1.0	Integrated DNA Technologies	https://www.idtdna.com/pages/products/next-generation-sequencing/hybridization-capture/lockdown-panels/xgen-exome-research-panel
ExAC Browser (Beta)	Exome Aggregation Consortium	http://exac.broadinstitute.org/
gnomAD Browser	genome Aggregation Database	http://gnomad-old.broadinstitute.org/