Table 6.

Recommended follow-up and intervention strategies for mutant-type and wild-type Peutz-Jeghers syndrome

Age (yr)	Mutant-type		Wild-type
	Surveillance	Intervention	Surveillance	Intervention
< 7	Routine abdominal ultrasound surveillance is recommended every year	Removal of polyps	Abdominal ultrasound is recommended every 3-5 yr	Follow-up observation
8-11	Routine abdominal ultrasound surveillance is recommended every year. For symptomatic individuals with PJS, an abdominal ultrasound should be performed earlier	Removal of polyps	Abdominal ultrasound is recommended every 3-5 yr. For symptomatic individuals with PJS, an abdominal ultrasound should be performed earlier	Removal of polyps
8-18	Total GI surveillance every year (CT scan of small-bowel or enteroscopy/capsule endoscopy should be offered as options	Polyps > 10 mm should be removed	Total GI surveillance 2-3 yr	Removal of polyps
19-30	Routine total GI polyps surveillance every 2-3 yr and screening for systemic tumors	Removal of polyps and treatment of tumors	Routine total GI polyps surveillance every 2-3 yr	Removal of polyps
> 30	Focus on detection of tumors in digestive tract and other organs	Treatment of tumors	Focus on detection of tumors in digestive tract and other organs	Treatment of tumors

PJS: Peutz-Jeghers syndrome; GI: Gastrointestina; CT: Computed tomography.