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. 2023 Jun 26;222(9):e202207060. doi: 10.1083/jcb.202207060

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© 2023 Choudhry et al.

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Figure 5. — Nup170 functions in subtelomeric silencing and replication checkpoint but does not affect SCC. (A) Enrichment of differentially expressed genes in the nup170∆, ctf18∆, dcc1∆, and ctf8∆ strains from the deleteome compendium according to gene distance from chromosome ends. X axis: distance from chromosome ends in 25-kb bins. Y axis: negative log₁₀ of the enrichment test’s FDR-adjusted P value. Dashed lines represent significance cutoff. (B) Log-phase cultures of the indicated strains were equalized in cellular density, serially diluted 10-fold, and spotted onto plates containing YPD with or without 100 mM HU. Plates were scanned after 2 d at 30°C. (C) SCC was assessed in three biological replicates for the indicated strains containing a lacO tandem repeat inserted at the TRP1 locus on chromosome IV and LacI-GFP. The number of GFP spots in each cell was scored and percentages of cells with two GFP spots are plotted.