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. 2023 Jun 26;4(4):e298. doi: 10.1002/mco2.298

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© 2023 The Authors. MedComm published by Sichuan International Medical Exchange & Promotion Association (SCIMEA) and John Wiley & Sons Australia, Ltd.

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Metabolic processes of iron transport by transcellular pathway (endocytosis), lipid peroxidation related to the occurrence of ferroptosis, and the body's representative antioxidant system. The Fenton reaction stimulated by liable iron induces lipid peroxidation, while intracellular GSH is insufficient to resist it due to the rapid rise of liable iron so ferroptosis occurs due to the rupture of the unstable membrane. Tf, transferrin; TfR, transferrin receptor; DMT1, divalent metal transporter 1; FPN, ferroportin; Cp, ceruloplasmin; Hp, hephaestin; ROS, reactive oxygen species; SLC7A11, solute carrier family 7 member 11; SLC3A2, solute carrier family 3 member 2; GSH, glutathione; GSSG, oxidized glutathione; GPX4, glutathione peroxidase 4.