FIGURE 2.

Timeline of microglia and iron after hemorrhage stroke (A) and ischemic stroke (B). These timelines are based on the data from the male rat model of AIS and HS. ⁹⁵ , ⁹⁶ , ⁹⁷ , ⁹⁸ Iron deposition in hemorrhage stroke is more rapid than in ischemic stroke due to the release of iron by the dissolution of mass red blood cells. The microglia numbers decrease (the red cycle) in the peri‐hematoma area shortly after HS, which might ascribe to necroptosis, and apoptosis caused by iron release from the hematoma, and significantly increase and peak at days 3−7. In contrast, microglia numbers in the core infarct area reach the peak during days 7−14 after IS and return to normal after day 28. Therefore, the reaction speed and proliferation ability of microglia cells were stronger in hemorrhage stroke, leading to an earlier peaking time of microglia proliferation as well as the earlier switch of the microglial phenotype (M1–M2).