Skip to main content
. 2023 Jun 26;4(4):e298. doi: 10.1002/mco2.298

TABLE 2.

Ferroptosis inhibitors for neurological diseases

Name Mechanism/effect Target disease References
N‐acetylcysteine ↓Toxic arachidonic acid products of nuclear ALOX5 HS 296
PD146176 ↓SSAT1/ALOX15 axis IS 297
Naotaifang

  1. ↓TfR1 and DMT1

  2. ↑SLC7A11, GPX4 and GSH

 IS 298
ADA‐409‐052

↓TBHP‐induced lipid peroxidation

↓Activation of BV2 microglia

Maintain mitochondrial morphology

 IS 299
Thiazolidinediones ↓ACSL4 activity selectively IS 300
Rosiglitazone ↓ACSL4 activity selectively IS 301
(R)‐HTS‐3 ↓LPCAT3 activity selectively – 302
Baicalin ↑The mRNA expression of GPX4 and SLC7A11 in the peri‐hematoma brain tissues HS 303
Dauricine ↑GPX4 and glutathione reductase coexpression HS 304
Melatonin ↓5‐LOX level by circPtpn14/miR‐351‐5p signaling TBI 305
DHI ↑SATB1/SLC7A11/HO‐1 pathway IS 306
β‐Caryophyllene ↑Nrf2/HO‐1 signaling pathway IS 307
Eriodictyol

  1. Aβ aggregation and p‐tau

  2. ↑Nrf2/HO‐1 pathway through VDR

 AD 308
α‐Lipoic acid

↓p‐tau

Iron redistribution mediated by TfR and Fpn1

 PD 309
TS, TP Inhibit 15‐LOX by competing for the substrate binding site of PUFA _ 310

Note: ↑, activate/upregulate;↓, inhibit/suppress.

Abbreviations: HS, hemorrhagic stroke; SSAT1, spermidine/spermine N1‐acetyltransferase 1; ALOX5, arachidonate 5‐lipoxygenase; IS, ischemic stroke; TfR1, transferrin receptor 1; DMT1, divalent metal transporter 1; SLC7A11, solute carrier family 7 member 11; GPX4, glutathione peroxidase 4; GSH, glutathione; TBHP, tert‐Butyl hydroperoxide; ACSL4, Acyl‐CoA synthetase long‐chain family member 4; LPCAT3, lysophosphatidylcholine acyltransferase 3; 5‐LOX, 5‐lipoxygenase; TBI, traumatic brain injury; DHI, danhong injection; SATB1, special AT‐rich sequence‐binding protein 1; SLC7A11, solute carrier family 7 member 11; HO‐1, heme oxygenase‐1; Nrf2, nuclear factor erythroid 2‐related factor 2; Aβ, β‐amyloid; VDR, vitamin D receptor; p‐tau, phosphorylated tau; TfR, transferrin receptor; Fpn1, ferroportin 1; TS, α‐Tocopherol succinate; TP, α‐Tocopherol phosphate; 15‐LOX, 15‐lipoxygenase; PUFA, polyunsaturated fatty acids.