Table 2. Incidence rates per 100,000 and average annual change of IPD among the people 65 years old and older, by vaccine serotypes, in 2010–2019 in Denmark, Finland, Norway and Sweden.
| 2010 | 2011 | 2012 | 2013 | 2014 | 2015 | 2016 | 2017 | 2018 | 2019 | Average annual change over study period (%) (95% confidence interval) | p-value | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Denmark | ||||||||||||
| Total | 54.0 | 52.2 | 50.9 | 43.3 | 42.9 | 48.5 | 41.9 | 42.7 | 46.6 | 35.1 | -3.3 (-5.6, -1.1) | <0.01 |
| PCV10 | 19.1 | 15.5 | 13.4 | 7.9 | 6.5 | 4.6 | 2.1 | 1.7 | 1.4 | 1.2 | -34.4 (-38.4, -30.5) | <0.01 |
| PCV13-non-PCV10 | 10.5 | 10.5 | 6.8 | 5.8 | 5.1 | 5.5 | 5.6 | 3.6 | 5.0 | 4.7 | -9.6 (-14.7, -4.5) | <0.01 |
| PCV13 | 29.5 | 26.0 | 20.2 | 13.7 | 11.6 | 10.2 | 7.7 | 5.2 | 6.3 | 5.9 | -20.0 (-24.5, -15.6) | <0.01 |
| PCV15-non-PCV13 | 5.2 | 4.6 | 6.7 | 4.8 | 5.4 | 6.1 | 4.5 | 5.0 | 5.7 | 3.9 | -1.6 (-6.0, 2.8) | 0.42 |
| PCV15 | 34.7 | 30.6 | 27.0 | 18.6 | 16.9 | 16.3 | 12.2 | 10.2 | 12.0 | 9.7 | -14.6 (-17.5, -11.7) | <0.01 |
| PCV20-non-PCV15 | 7.9 | 8.8 | 8.4 | 11.0 | 10.8 | 16.0 | 14.2 | 16.7 | 16.1 | 13.0 | 8.1 (3.8, 12.3) | <0.01 |
| PCV20 | 42.6 | 39.4 | 35.4 | 29.6 | 27.7 | 32.3 | 26.4 | 26.9 | 28.1 | 22.7 | -5.8 (-7.7, -3.9) | 0.03 |
| PPV23 | 44.4 | 42.0 | 38.9 | 32.8 | 31.2 | 36.3 | 31.4 | 32.2 | 34.3 | 25.8 | -4.4 (-6.8, -2.0) | <0.01 |
| PPV23-non-PCV13 | 15.6 | 16.6 | 18.6 | 19.3 | 19.9 | 26.1 | 23.7 | 27.0 | 27.9 | 19.9 | 5.2 (0.7, 9.7) | 0.03 |
| PPV23-non-PCV20 | 2.6 | 3.2 | 3.5 | 3.5 | 3.7 | 4.0 | 5.0 | 5.3 | 6.2 | 3.1 | 5.7 (-2.2, 13.6) | 0.14 |
| Finland | ||||||||||||
| Total | 32.3 | 30.4 | 33.7 | 30.2 | 32.5 | 38.0 | 36.1 | 37.2 | 32.5 | 31.4 | 0.9 (-1.0, 2.7) | 0.32 |
| PCV10 | 18.5 | 15.4 | 14.8 | 10.7 | 8.6 | 6.7 | 4.9 | 3.9 | 3.9 | 1.6 | -25.0 (-31.7, -18.3) | <0.01 |
| PCV13-non-PCV10 | 5.9 | 6.4 | 6.3 | 7.8 | 11.2 | 13.5 | 14.3 | 15.8 | 12.0 | 11.5 | 10.3 (4.9, 15.8) | <0.01 |
| PCV13 | 24.4 | 21.8 | 21.1 | 18.5 | 19.8 | 20.3 | 19.2 | 19.7 | 15.9 | 13.1 | -4.9 (-7.5, -2.2) | <0.01 |
| PCV15-non-PCV13 | 2.5 | 2.8 | 2.7 | 2.7 | 3.9 | 4.5 | 4.9 | 3.7 | 3.2 | 3.8 | 5.1 (1.3, 8.8) | 0.01 |
| PCV15 | 26.8 | 24.6 | 23.8 | 21.1 | 23.7 | 24.7 | 24.1 | 23.4 | 19.1 | 16.9 | -5.0 (-9.2, -0.9) | 0.01 |
| PCV20-non-PCV15 | 0.7 | 1.8 | 2.4 | 2.3 | 2.7 | 2.9 | 2.8 | 2.6 | 2.6 | 3.5 | 11.4 (0.5, 22.2) | 0.04 |
| PCV20 | 27.5 | 26.4 | 26.2 | 23.4 | 26.4 | 27.6 | 26.8 | 26.0 | 21.7 | 20.4 | -2.2 (-4.2, -0.2) | 0.03 |
| PPV23 | 27.7 | 26.6 | 27.2 | 24.0 | 25.9 | 27.5 | 26.7 | 26.4 | 22.3 | 21.3 | -2.1 (-3.8, -0.4) | 0.02 |
| PPV23-non-PCV13 | 4.8 | 5.9 | 6.7 | 6.5 | 7.8 | 8.3 | 8.4 | 7.6 | 7.1 | 8.3 | 4.7 (1.5, 7.9) | 0.01 |
| PPV23-non-PCV20 | 1.7 | 1.3 | 1.6 | 1.6 | 1.2 | 1.0 | 0.7 | 1.3 | 1.3 | 1.1 | -5.0 (-9.2, -0.9) | 0.02 |
| Norway | ||||||||||||
| Total | 54.0 | 51.5 | 42.6 | 38.8 | 38.3 | 37.4 | 44.1 | 37.8 | 38.5 | 38.1 | -3.3 (-5.5, -1.0) | <0.01 |
| PCV10 | 14.8 | 13.3 | 9.8 | 6.3 | 5.6 | 3.0 | 3.1 | 1.7 | 1.3 | 1.8 | -28.2 (-34.3, -22.2) | <0.01 |
| PCV13-non-PCV10 | 12.4 | 11.4 | 8.4 | 4.9 | 4.9 | 4.4 | 5.8 | 6.8 | 6.1 | 5.5 | -7.5 (-13.9, -1.0) | 0.03 |
| PCV13 | 27.2 | 24.7 | 18.2 | 11.2 | 10.5 | 7.4 | 8.9 | 8.6 | 7.4 | 7.3 | -15.2 (-20.1, -10.2) | <0.01 |
| PCV15-non-PCV13 | 8.5 | 9.2 | 7.4 | 9.6 | 6.9 | 9.7 | 11.6 | 7.9 | 8.4 | 6.5 | -1.1 (-4.9, 2.7) | 0.52 |
| PCV15 | 35.7 | 33.9 | 25.6 | 20.7 | 17.4 | 17.1 | 20.5 | 16.5 | 15.8 | 13.7 | -9.8 (-15.5, -7.1) | <0.01 |
| PCV20-non-PCV15 | 5.2 | 4.9 | 4.8 | 5.1 | 5.4 | 4.9 | 6.9 | 5.7 | 6.7 | 6.5 | 3.5 (1.7, 5.2) | <0.01 |
| PCV20 | 40.9 | 38.8 | 30.4 | 25.8 | 22.8 | 22.0 | 27.3 | 22.2 | 22.5 | 20.2 | -7.0 (-9.7, -4.4) | <0.01 |
| PPV23 | 40.3 | 39.3 | 31.1 | 26.6 | 24.8 | 23.3 | 29.2 | 26.2 | 25.3 | 25.3 | -4.8 (-7.7, -1.8) | <0.01 |
| PPV23-non-PCV13 | 14.5 | 15.5 | 13.5 | 15.7 | 14.4 | 16.1 | 20.4 | 17.8 | 18.1 | 18.1 | 3.2 (1.7, 4.7) | <0.01 |
| PPV23-non-PCV20 | 0.9 | 1.4 | 1.3 | 1.0 | 2.1 | 1.6 | 1.9 | 4.2 | 3.0 | 5.1 | 17.4 (11.9, 23.0) | <0.01 |
| Sweden | ||||||||||||
| Total | 47.0 | 41.1 | 44.3 | 41.6 | 38.6 | 41.1 | 43.7 | 42.9 | 41.9 | 41.8 | -0.5 (-1.9, 0.8) | 0.39 |
| PCV10 | N/A | 11.5 | 9.3 | 5.7 | 5.1 | 3.1 | 2.8 | 2.2 | 1.8 | 1.7 | -25.4 (-29.7, -21.0) | <0.01 |
| PCV13-non-PCV10 | N/A | 10.3 | 10.3 | 11.4 | 8.7 | 9.8 | 9.6 | 10.3 | 12.0 | 10.7 | 0.8 (-1.4, 3.1) | 0.41 |
| PCV13 | N/A | 21.8 | 19.6 | 17.1 | 13.8 | 12.9 | 12.4 | 12.5 | 13.8 | 12.4 | -6.8 (-8.7, -5.0) | <0.01 |
| PCV15-non-PCV 13 | N/A | 6.7 | 7.1 | 7.0 | 6.6 | 6.1 | 6.3 | 5.4 | 5.0 | 3.5 | -7.2 (-12.3, -2.0) | 0.01 |
| PCV15 | N/A | 28.5 | 26.8 | 24.1 | 20.4 | 19.0 | 18.7 | 17.9 | 18.8 | 15.8 | -6.8 (-8.7, -5.0) | <0.01 |
| PCV20-non-PCV 15 | N/A | 3.3 | 4.5 | 4.9 | 4.2 | 6.2 | 7.3 | 7.1 | 6.8 | 8.1 | 10.2 (6.9, 13.5) | <0.01 |
| PCV20 | N/A | 31.8 | 31.3 | 29.0 | 24.6 | 25.2 | 26.0 | 24.9 | 25.5 | 24.0 | -3.3 (-4.7, -1.9) | <0.01 |
| PCV13 | N/A | 21.8 | 19.6 | 17.1 | 13.8 | 12.9 | 12.4 | 12.5 | 13.8 | 12.4 | -6.8 (-8.7, -5.0) | <0.01 |
| PPV23 | N/A | 31.1 | 32.6 | 30.1 | 26.7 | 28.0 | 29.0 | 27.2 | 28.1 | 26.6 | -2.0 (-3.1, -0.8) | <0.01 |
| PPV23-non-PCV13 | N/A | 11.8 | 13.7 | 14.1 | 13.2 | 15.5 | 16.9 | 15.2 | 14.5 | 14.5 | 2.3 (-0.2, 4.8) | 0.07 |
| PPV23-non-PCV20 | N/A | 1.9 | 2.0 | 2.2 | 2.5 | 3.1 | 3.3 | 2.8 | 2.7 | 2.9 | 5.8 (2.6, 9.1) | <0.01 |