Table 1.
Biochemical parameters of lipid profile (total cholesterol – Chol; low density lipoprotein – LDL; blood glucose – Glu; triacylglycerols – TG) and blood pressure (BP) measured in hereditary hypertriglyceridemic (HTG) rats. BP measured at the beginning of the experiment (BP-basal) and at the end of 5 weeks dietary intervention (BP-end).
| Chol (mmol/l) | LDL (mmol/l) | Glu (mmol/l) | TG (mmol/l) | BP-basal (mm Hg) | BP-end (mm Hg) | |
|---|---|---|---|---|---|---|
| SD | 1.48±0.08 | 0.52±0.07 | 7.34±0.25 | 1.53±0.19 | 146.34±1.60 | 151.12±1.65 |
| HFFD | 3.96±0.33*** | 2.62±0.38*** | 8.30±0.16** | 1.84±0.28 | 142.06±2.28 | 153.82±1.96§§ |
| HFFD+SMe | 3.41±0.23*** | 2.24±0.25*** | 8.00±0.38 | 1.67±0.16 | 141.27±2.16 | 139.48±2.83*,# |
| HFFD+VitE | 3.31±0.18*** | 2.20±0.27***,# | 7.68±0.39 | 1.56±0.14 | 143.22±1.86 | 140.68±2.03*,# |
| HFFD+SMe+VitE | 3.30±0.33*** | 2.62±0.40*** | 7.66±0.69 | 1.75±0.19 | 143.60±1.76 | 130.96±2.15**,##,§§§ |
SD – standard diet; HFFD – high fat fructose diet; vitE – vitamin E; SMe – synthetic pyridoindole antioxidant SMe1EC2; Data are expressed as mean values ± SEM. The significant differences marked as * p<0.05; ** p<0.01; *** p<0.001; * vs. SD; # p<0.05; ## p<0.01; # vs. HFFD; §§ p<0.01; §§§ p<0.001; § BP-end vs. BP-basal.