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. 2023 Jun 12;10:1191315. doi: 10.3389/fmed.2023.1191315

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Copyright © 2023 Cruz-Nova, Gibbens-Bandala, Ancira-Cortez, Ramírez-Nava, Santos-Cuevas, Luna-Gutiérrez and Ocampo-García.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Schematic representation of the ¹⁷⁷Lu-PLGA(RGF)-CXCR4L synthesis for combined therapy. (A) Microfluidic device (Droplet Junction Chip). (B) Synthesis of PLGA-entrapped RGF nanoparticles. (C) Functionalization of PLGA nanoparticles with CXCR4L. (D) Functionalization of PLGA(RGF)-CXCR4L nanoparticles with DOTA. (E) Radiolabeling of DOTA-PLGA(RGF)-CXCR4L with ¹⁷⁷Lu.