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. 2023 Jun 12;10:1191315. doi: 10.3389/fmed.2023.1191315

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Copyright © 2023 Cruz-Nova, Gibbens-Bandala, Ancira-Cortez, Ramírez-Nava, Santos-Cuevas, Luna-Gutiérrez and Ocampo-García.

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Therapeutic in vivo efficacy of the ¹⁷⁷Lu-PLGA(RGF)-CXCR4L nanosystem. (A) Twice -intravenously-administered treatments, with and without CXCR4L, reduce the tumor size in murine colorectal cancer xenografts, compared to free RGF and control (untreated). n = 3; ^***p < 0.001. Error bars represent SEM. (B) Survival rate for each experimental group. (C) Representative images of immunohistochemical staining for Ki67 (a marker of proliferation) in the xenograft tumor tissues. The scale bar represents 200 μM.