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. 2023 Jun 12;10:1191315. doi: 10.3389/fmed.2023.1191315

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Copyright © 2023 Cruz-Nova, Gibbens-Bandala, Ancira-Cortez, Ramírez-Nava, Santos-Cuevas, Luna-Gutiérrez and Ocampo-García.

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Influence of the selected factors for the optimal nanoparticle formulation. (A) Hydrodynamic size, (B) ζ potential, and (C) Polydispersity index (PDI). PLGA nanoparticles were produced via a microfluidic device, by adjusting PLGA (10% w/v) and PVA (0.25, 0.5, 1, and 1.5% w/v) concentration and controlling the flow rates of the continuous and dispersed phases. The flow rates oscillate between 50/1,000 and 100/1,000 (organic/aqueous phases). The concentration of RGF was 0.5, 1, and 1.5 mg/mL in acetone. Three batches were prepared and the stability was followed by measuring the hydrodynamic diameter and z potential.