Table 2.

Ligand enabled C(sp²)─H hydroxylation of phenylacetic acids^a

^aConditions: Carboxylic acid 1 (1 mmol), Pd(OAc)₂ (2 mol%), L4 (4 mol%), H₂O₂ (35% aqueous solution, 3.5 equiv.), and K₂HPO₄ (1.5 equiv.) in CH₃CN (3.0 mL), r.t., 24 h. Isolated yields.

^bKHCO₃ (2 mmol) instead of K₂HPO₄, DMA instead of CH₃CN.

^c60 °C.

^dIsolated yield based on the corresponding lactone. (See SI for details)

^e0.5 mmol scale.