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. Author manuscript; available in PMC: 2023 Oct 1.
Published in final edited form as: Nature. 2022 Aug 9;610(7930):87–93. doi: 10.1038/s41586-022-05175-1

Fig. 4. Synthetic applications.

Fig. 4.

a, Late-stage remote site-selective C–H modification of camptothecin. Reaction conditions are provided in Supplementary Information 2.10. b, Synthesis of cabozantinib analogue through C6–H olefination. c, Synthesis of chloroquine analogue through C6–H alkynylation. d, Molecular editing of quinoline through iterative C–H activation in different orders. Reaction conditions are provided in Supplementary Information 2.13. Deuterium incorporation is shown in square brackets.