Fig. 5.
Dependencies between antibiotics. The detected significant dependent mutations between resistance-conferring mutations follow a particular order that mirrors the usage of different antibiotics. For each antibiotic, we took the top dependent pair between known resistance-conferring genes and other genes and between known resistance genes for different antibiotics. We display pairs and links where mutation a occurs sequentially or simultaneously with mutation b at least ten times. Link intensity corresponds to the number of occurrences. The prefix “p_” before a gene name indicates that the mutations are found in the upstream region of that gene. The drug para-aminosalicylic acid (PAS) is not included in the WHO catalog, but folC is a candidate resistance gene for this drug (Wei et al. 2019).