Table 2.
Pathway level information ExtractoR results
| LVs Built by PLIER | Interaction Effect | Timepoint Main Effect | Treatment Main Effect | Annotation (If Present) |
|---|---|---|---|---|
| LV1 | 0.002 | 0.000 | 0.001 | MIPS_NOP56P_ASSOCIATED_PRE_RRNA_COMPLEX |
| LV2 | 0.073 | 0.000 | 0.000 | MIPS_55S_RIBOSOME_MITOCHONDRIAL |
| LV3 | 0.000 | 0.005 | 0.083 | PID_AR_TF_PATHWAY |
| LV4 | 0.081 | 0.317 | 0.221 | N/A |
| LV5 | 0.002 | 0.000 | 0.008 | MIPS_SPLICEOSOME |
| LV6 | 0.039 | 0.083 | 0.022 | N/A |
| LV7 | 0.224 | 0.000 | 0.098 | REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION |
| LV8 | 0.811 | 0.383 | 0.501 | REACTOME_GPCR_DOWNSTREAM_SIGNALING |
| LV9 | 0.121 | 0.873 | 0.013 | KEGG_AXON_GUIDANCE |
| LV10 | 0.363 | 0.116 | 0.220 | KEGG_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION |
| LV11 | 0.847 | 0.249 | 0.274 | N/A |
| LV12 | 0.835 | 0.623 | 0.131 | REACTOME_GPCR_DOWNSTREAM_SIGNALING |
| LV13 | 0.148 | 0.369 | 0.139 | KEGG_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION |
| LV14 | 0.083 | 0.399 | 0.728 | N/A |
| LV15 | 0.270 | 0.936 | 0.288 | REACTOME_GPCR_DOWNSTREAM_SIGNALING |
| LV16 | 0.618 | 0.556 | 0.289 | N/A |
| LV17 | 0.778 | 0.807 | 0.280 | N/A |
| LV18 | 0.364 | 0.446 | 0.425 | PID_PLK1_PATHWAY |
LV, latent variable; PLIER, Pathway-Level Information ExtractoR. Significant values in bold.