Table 2. Random effects model estimates of mean intraocular pressure, proportion of success, and number of glaucoma medications.
Data were analyzed at 12 and 24 months after glaucoma drainage device implantation. Results are listed for all studies and separately for device type and etiology group. Meta-regression test for subgroup differences were performed when each subgroup had 2 or more studies quantitatively summarized. P-value less than 0.05 was considered significant.
| Overall | Device Type | Etiology | ||||||
|---|---|---|---|---|---|---|---|---|
| Ahmed | Baerveldt | Subgroup difference, device | Primary | GFCS | Other Secondary | Subgroup difference, etiology | ||
| IOP, mmHg | ||||||||
| 12 months | 16.5 [15.5, 17.6) | 16.4 [15.5–17.4] | 16.0 [8.9 – 23.2] | p = 0.89 | 15.4 [14.2–16.6] | -- | 18.1 [12.9–23.3] | p = 0.26 |
| I2 | 89.3% | 86.4% | 92.6% | 86.3% | -- | 60.3% | ||
| Studies (eyes) | 13 (414) | 11 (364) | 2 (50) | 7 (153) | 0 | 2 (19) | ||
| 24 months | 17.6 [16.4–18.7] | 17.5 [16.2–18.8] | 18.3 [16.9–19.7] | --a | 18.1 [17.8–18.5] | -- | 14.9 [13.7–16.1] | -- |
| I2 | 83.3% | 84.7% | -- | 0% | -- | -- | ||
| Studies (eyes) | 8 (297) | 7 (252) | 1 (45) | 2 (44) | 0 | 1 (16) | ||
| Proportion of Success | ||||||||
| 12 months | 0.87 [0.83–0.91] | 0.86 [0.81–0.90] | 0.92 [0.86 – 0.99] | p = 0.29 | 0.83 [0.74–0.93] | 0.91 [0.81–1.01] | 0.92 [0.84–1.00] | p = 0.34 |
| I2 | 78.6% | 82.2% | 42.3% | 83.6% | 83.8% | 0% | ||
| Studies (eyes) | 23 (1040) | 19 (920) | 4 (120) | 8 (205) | 4 (145) | 2 (47) | ||
| 24 months | 0.77 [0.71–0.83] | 0.75 [0.68–0.83] | 0.85 [0.77–0.92] | p = 0.34 | 0.75 [0.56–0.94] | 0.82 [0.73–0.92] | 0.70 [0.21–1.18] | p = 0.92 |
| I2 | 74.6% | 78.6% | 0% | 88.6% | 58.7% | 88.4% | ||
| Studies (eyes) | 16 (577) | 13 (490) | 3 (87) | 5 (127) | 4 (145) | 2 (47) | ||
| Medicatio ns | ||||||||
| 12 months | 1.2 [0.8–1.6] | 1.3 [0.9–1.7] | 0.80 [0.1–1.5] | -- | 1.1 [0.7–1.4] | -- | 1.8 [−0.9–4.6] | p = 0.53 |
| I2 | 72.7% | 78.3% | -- | 0% | -- | 93.9% | ||
| Studies (eyes) | 6 (130) | 5 (125) | 1 (5) | 3 (30) | 0 | 2 (19) | ||
| 24 months | 1.2 [0.8–1.7] | 1.2 [0.8–1.7] | -- | -- | 1.3 [0.5–2.0] | -- | 0.4 [−0.0–0.8] | -- |
| I2 | 78.9% | 78.9% | -- | |||||
| Studies (eyes) | 3 (108) | 3 (108) | 1 (11) | 0 | 1 (16) | |||
For subgroups that contained only one study, the data entry reflects the results from the study rather than result from a random effects model
a
For subgroups that contained only one study, test for subgroup differences was not performed.
Abbreviations: IOP (intraocular pressure), GFCS (glaucoma following cataract surgery)