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. Author manuscript; available in PMC: 2023 Jul 1.
Published in final edited form as: J Invest Dermatol. 2023 Jan 26;143(7):1299–1302.e3. doi: 10.1016/j.jid.2022.12.021

Figure 1: Spatial Profiling identifies the greatest transcriptional change in the cytokeratin negative compartment comparing sun-protected skin with actinic keratosis.

Figure 1:

a: Digital Spatial Profiler identified regions of interest (ROI) highlights examples of areas of patient tissue sampled for transcriptional profiling. b: Differentially expressed genes identified using a pairwise FDR adjusted p-value of less than 0.05 and an overall t-test statistic of 0.05 highlights greater number DEGs (y-axis) in the cytokeratin negative compartment (CK-) comparing sun protected normal skin (SP) with actinic keratosis center (Cen). CK+ = cytokeratin positive compartment, Edge = actinic keratosis edge.