Table 2.
Baseline demographic and laboratory data of alcohol-associated hepatitis cohorts confirmed dead or alive at 180 days included for mortality statistics.
| n | Total (n=37) | New Cohort (n=10) | Prior Cohort (n=27) | P value | |
|---|---|---|---|---|---|
| Gender (male), n | 37 | 23 (62.2%) | 6 (60.0%) | 17 (63.0%) | 1.000 |
| Age (years) | 37 | 50.0 [41.0;56.0] | 51.1 [41.5;55.6] | 50.0 [42.2;57.3] | 0.837 |
| BMI (kg/m2) | 34 | 27.6 [24.1;31.7] | 28.5 [26.1;36.7] | 27.2 [23.1;31.3] | 0.335 |
| AST (IU/L) | 37 | 136 [98.0;217] | 190 [92.5;241] | 128 [101;176] | 0.505 |
| ALT (IU/L) | 37 | 48.0 [29.0;72.0] | 60.5 [28.2;74.0] | 48.0 [29.5;71.5] | 0.905 |
| GGT (IU/L) | 20 | 130 [87.0;293] | 143 [137;348] | 120 [86.0;230] | 0.432 |
| AP (IU/L) | 36 | 164 [124;232] | 186 [165;233] | 135 [117;225] | 0.258 |
| Bilirubin (mg/dL) | 37 | 17.3 [9.95;20.5] | 14.8 [7.02;19.7] | 17.7 [10.9;21.0] | 0.356 |
| Albumin (g/dL) | 34 | 2.40 [2.02;2.88] | 2.45 [2.10;2.90] | 2.35 [1.98;2.82] | 0.623 |
| INR | 37 | 2.00 [1.70;2.50] | 2.05 [1.82;2.45] | 2.00 [1.65;2.48] | 0.837 |
| Creatinine (mg/dL) | 37 | 0.99 [0.62;1.37] | 0.99 [0.64;1.51] | 0.99 [0.62;1.26] | 0.771 |
| Platelets (109/L) | 35 | 115 [68.0;154] | 83.5 [71.5;170] | 123 [67.0;146] | 0.913 |
| MELD | 37 | 25.6 [22.5;32.5] | 27.4 [21.3;32.0] | 25.3 [22.7;30.5] | 0.824 |
| FIB-4 | 35 | 9.47 [6.29;16.5] | 9.48 [6.82;17.5] | 9.47 [6.06;15.6] | 0.884 |
| FIB-4 > 3.25 (F3-F4), n | 35 | 34 (97.1%) | 9 (90.0%) | 25 (100%) | 0.286 |
| Cytolysin positive, n | 37 | 22 (59.5%) | 3 (30.0%) | 19 (70.4%) | 0.056 |
Values are presented as median and interquartile range in brackets. The number of subjects for which data were available is indicated in the second column. Continuous variables were compared using the Mann-Whitney test. Categorical variables were compared using the Pearson’s Chi-squared test. Level for statistical significance is P<0.05. ALT, alanine aminotransferase; AP, alkaline phosphatase; AST, aspartate aminotransferase; BMI, body mass index; FIB-4, Fibrosis-4 Index; GGT, gamma-glutamyltransferase; INR, international normalized ratio; MELD, model for end-stage liver disease.