Table 3.

Predictive accuracy for mortality of cytolysin in comparison with established liver disease markers.

	AUC	Threshold	Sens	Spec	Acc	Prec	PPV	NPV
Cytolysin	0.82	detectable	0.75	0.89	0.78	0.95	0.95	0.53
FIB-4	0.69	6.53	0.82	0.71	0.80	0.92	0.92	0.50
ABIC	0.77	8.28	0.71	0.78	0.73	0.91	0.91	0.47
Maddrey’s DF	0.68	29.17	1.00	0.40	0.88	0.86	0.86	1.00
MELD	0.80	25.13	0.68	0.89	0.73	0.95	0.95	0.47

The best threshold was determined to maximize the youden index (= sensitivity + specificity) for each marker. Cytolysin n=37, FIB-4 n=35, ABIC n=37, Maddrey’s DF n=24, and MELD score n=37. ABIC, Age, serum bilirubin, INR, and serum creatinine score; acc, accuracy; AUC, area under the curve; FIB-4, Fibrosis-4 Index; INR, international normalized ratio; Maddrey’s DF, Maddrey’s discriminant function; MELD, model for end-stage liver disease; NPV, negative predictive value; PPV, positive predictive value; pre, precision; sens, sensitivity; spec, specificity.