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. 2023 May 15;17(2):299–312. doi: 10.1007/s12105-023-01548-8

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Fig. 7 — IDH2-mutant sinonasal carcinomas are consistently positive for keratin (A, × 20). Tumors with neuroendocrine and neuroepithelial differentiation show expression of neuroendocrine markers such as INSM1 (B, × 20). Neuroepithelial tumors also frequently have an S100-protein-positive sustentacular network (C, × 20). Mutant IDH1/IDH2 immunohistochemistry demonstrates strong cytoplasmic positivity in tumor cells (D, × 20)