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. 2023 Jun 26;13:10374. doi: 10.1038/s41598-023-37496-0

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Effect of AR42 on motor neuron loss in the lumbar spinal cords of SMNΔ7 SMA mice. SMNΔ7 SMA mice (n = 3/group) were treated with either AR42 or vehicle from PND04 until PND11. The number of Cresyl violet-positive, ventral motor neurons were counted in every 12th section of lumbar spinal cords of AR42-treated SMNΔ7 SMA mice (circles), vehicle-treated SMNΔ7 SMA mice (squares) or age-matched non-SMA littermates (triangles). AR42 increased lumbar spinal motor neuron counts in SMNΔ7 SMA mice to levels similar to those in nonSMA littermates. The data are presented as mean ± standard error with the average motor neuron counts/section shown for each individual mouse. The asterisk (*) denotes a statistically significant (p ≤ 0.05; one-way ANOVA with Bonferonni post hoc test) difference when compared to vehicle-treated SMNΔ7 SMA mice.