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. 2023 Jun 26;13(1):98. doi: 10.1038/s41408-023-00872-0

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — A UCSC browser view showing the TERT promoter region (5′ end of TERT gene indicated by black color with a black arrow indicating the transcription direction) and the CpG island located in this region (indicated in green color according to the CpG Islands Track from the UCSC browser). The TERT core promoter and the THOR region are indicated in blue and orange, respectively. CpGs present on the Illumina HumanMethylation 450k array are labeled with their TargetID. B DNA methylation data of 155 hematopoietic cell lines [3 lymphoblastic cell lines (LCL), 4 chronic lymphocytic leukemia (CLL), 4 mantle cell lymphoma (MCL), 33 diffuse large B-cell lymphomas (DLBCL), 5 large B-cell lymphoma (LBCL), 18 Burkitt lymphoma (BL), 16 multiple myelomas (MM), 10 classic Hodgkin lymphoma (cHL, including 2 T-lineage cell lines; HDLM-2 and L-540), 17 T-cell leukemia, 5 anaplastic large-cell lymphomas (ALCL), 29 acute myeloid leukemia (AML), 11 chronic myeloid leukemia (CML)]. DNA methylation is shown for two CpGs, one located in the TERT core promoter, and the other in the THOR. T-cell and myeloid malignancies are separated from the rest samples with black lines.