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. 2023 May 22;30(30):75126–75140. doi: 10.1007/s11356-023-27747-y

Table 2.

Genotoxicity of BPA, TBBPA, BPF, and BPS with/without liver metabolism induced by rat liver S9

Sample concentrations (µM) CIF
BPA TBBPA BPF BPS
 − S9  + S9  − S9  + S9  − S9  + S9  − S9  + S9
500 2.76 (± 0.33) 1.18 (± 0.18) 3.51 (± 0.36) 1.01 (± 0.12) 2.88 (± 0.15) 0.97 (± 0.02) 3.17 (± 0.22) 0.89 (± 0.09)
250 2.63 (± 0.20) 1.62 (± 0.02) 2.89 (± 0.14) 1.14 (± 0.09) 3.32 (± 0.09) 1.28 (± 0.15) 3.11 (± 0.12) 1.34 (± 0.07)
125 2.86 (± 0.18) 1.66 (± 0.09) 3.16 (± 0.21) 1.33 (± 0.05) 2.60 (± 0.06) 1.34 (± 0.09) 2.95 (± 0.20) 1.51 (± 0.08)
62.5 3.96 (± 0.35) 1.63 (± 0.21) 3.61 (± 0.15) 1.69 (± 0.12) 2.46 (± 0.04) 1.48 (± 0.06) 2.02 (± 0.13) 1.72 (± 0.14)
31.25 2.55 (± 0.17) 1.75 (± 0.18) 2.17 (± 0.08) 1.57 (± 0.11) 3.93 (± 0.21) 1.66 (± 0.02) 3.23 (± 0.12) 1.29 (± 0.12)
15.62 4.03 (± 0.30) 1.68 (± 0.20) 2.74 (± 0.11) 1.37 (± 0.13) 3.05 (± 0.24) 1.24 (± 0.06) 3.01 (± 0.15) 1.30 (± 0.09)
7.81 3.15 (± 0.21) 0.90 (± 0.01) 2.91 (± 0.14) 1.24 (± 0.16) 3.68 (± 0.17) 1.21 (± 0.10) 3.54 (± 0.09) 1.23 (± 0.01)

CIF – corrected induction factor, genotoxic samples are indicated in bold and shaded (CIF˃1.2), ± SD (standard deviation)