Table 2.
Genotoxicity of BPA, TBBPA, BPF, and BPS with/without liver metabolism induced by rat liver S9
| Sample concentrations (µM) | CIF | |||||||
|---|---|---|---|---|---|---|---|---|
| BPA | TBBPA | BPF | BPS | |||||
| − S9 | + S9 | − S9 | + S9 | − S9 | + S9 | − S9 | + S9 | |
| 500 | 2.76 (± 0.33) | 1.18 (± 0.18) | 3.51 (± 0.36) | 1.01 (± 0.12) | 2.88 (± 0.15) | 0.97 (± 0.02) | 3.17 (± 0.22) | 0.89 (± 0.09) |
| 250 | 2.63 (± 0.20) | 1.62 (± 0.02) | 2.89 (± 0.14) | 1.14 (± 0.09) | 3.32 (± 0.09) | 1.28 (± 0.15) | 3.11 (± 0.12) | 1.34 (± 0.07) |
| 125 | 2.86 (± 0.18) | 1.66 (± 0.09) | 3.16 (± 0.21) | 1.33 (± 0.05) | 2.60 (± 0.06) | 1.34 (± 0.09) | 2.95 (± 0.20) | 1.51 (± 0.08) |
| 62.5 | 3.96 (± 0.35) | 1.63 (± 0.21) | 3.61 (± 0.15) | 1.69 (± 0.12) | 2.46 (± 0.04) | 1.48 (± 0.06) | 2.02 (± 0.13) | 1.72 (± 0.14) |
| 31.25 | 2.55 (± 0.17) | 1.75 (± 0.18) | 2.17 (± 0.08) | 1.57 (± 0.11) | 3.93 (± 0.21) | 1.66 (± 0.02) | 3.23 (± 0.12) | 1.29 (± 0.12) |
| 15.62 | 4.03 (± 0.30) | 1.68 (± 0.20) | 2.74 (± 0.11) | 1.37 (± 0.13) | 3.05 (± 0.24) | 1.24 (± 0.06) | 3.01 (± 0.15) | 1.30 (± 0.09) |
| 7.81 | 3.15 (± 0.21) | 0.90 (± 0.01) | 2.91 (± 0.14) | 1.24 (± 0.16) | 3.68 (± 0.17) | 1.21 (± 0.10) | 3.54 (± 0.09) | 1.23 (± 0.01) |
CIF – corrected induction factor, genotoxic samples are indicated in bold and shaded (CIF˃1.2), ± SD (standard deviation)