. 2023 Apr 6;68(7):3158–3166. doi: 10.1007/s10620-023-07929-x

Table 3.

Peri- and postoperative characteristics

Author (year)		Brown and Zenati [18]	Brown and Jung [19]	Ito [20]	Ueda [21]	Asano [22]	Hiyoshi [23]	Malgras [24]	Parra-Membrives [25]
Sample size, n		628	241	133	113	213	161	352	86
Postoperative cholangitis, n (%)		50 (8)	27 (11)	28 (21)	21 (19)	16 (8)	13 (8)	20 (6)	14 (16)
Predictive peri- and postoperative characteristics
Operation type^a	n (%)	N/A	2 (1)	19 (14)	N/A	N/A	N/A	N/A	N/A
	mean ± SD
	P-value		0.344	0.10
	OR (95% CI)	2.24 (1.32–3.81)	N/A	N/A
	P-value	0.003	N/A	N/A
Operation time	n (%)	N/A	N/A	16 (12)	17 (15)	N/A	N/A	N/A	N/A
	mean ± SD		398.0 ± 64.0	N/A	N/A		636.5 ± 91.4		N/A
	P-value		0.05	0.72	< 0.001		0.21		0.395
	OR (95% CI)		1.01 (1.00–1.01)	N/A	18.7 (3.07–114)	1.55 (1.04–2.30)	N/A		N/A
	P-value		0.052	N/A	0.002	0.031	N/A		N/A
Blood loss	n (%)	N/A	6 (3)	16 (12)	15 (13)	N/A	N/A	N/A	N/A
	mean ± SD		N/A	N/A	N/A		1743.1 ± 546.6		N/A
	P-value		0.42	0.79	0.062		0.98		0.447
	OR (95% CI)		N/A	N/A	N/A	1.00 (0.99–1.00)	N/A		N/A
	P-value		N/A	N/A	N/A	0.051	N/A		N/A
Perioperative radiotherapy	n (%)	N/A	2 (1)	N/A	N/A	N/A	N/A	N/A	N/A
	mean ± SD		N/A
	P-value		0.11
	OR (95% CI)	1.84 (0.77–4.36)	9.00 (1.18–68.49)
	P-value	0.17	0.034
Malignant/benign	n (%)	N/A	N/A	27 (20)	14 (12)	N/A	N/A	N/A	N/A
	mean ± SD			N/A	N/A
	P-value			0.68	< 0.001
	OR (95% CI)			N/A	18.5 (3.56–100)	0.32 (0.11–0.39)		5.3 (1.8–15.8)
	P-value				0.001	0.035		0.001
Clavien–Dindo ≥ 3 (C-D)	n (%)	N/A	10 (4)	N/A	N/A	N/A	N/A	N/A	N/A
	mean ± SD		N/A
	P-value		0.072	N/A	N/A	N/A	N/A	N/A	N/A
	OR (95% CI)	1.56 (0.92–2.62)	N/A
	P-value	0.097	N/A
Small bile duct diameter	n (%)	N/A	N/A	N/A	13 (12)	N/A	N/A	N/A	N/A
	mean ± SD		6.6 ± 2.0		N/A		7.2 ± 2.1
	P-value		0.005		0.087		0.050
	OR (95% CI)		11.57 (1.54–86.94)		N/A		N/A	0.3 (0.1–1.2)
	P-value		0.017					0.09
Wound infection	n (%)	N/A	N/A	5 (4)	N/A	N/A	N/A	N/A	N/A
	mean ± SD			N/A
	P-value			0.83
	OR (95% CI)	1.00 (0.55–1.82)		N/A
	P-value	0.99		N/A
Length of stay	n (%)	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A
	mean ± SD	N/A	7 (5–9)^b
	P-value	N/A	0.36
	OR (95% CI)	1.00 (0.96–1.03)	N/A
	P-value	0.827	N/A
Readmission < 90 days	n (%)	N/A	16 (7)	N/A	N/A	N/A	N/A	N/A	N/A
	mean ± SD		N/A
	P-value		0.034
	OR (95% CI)	2.30 (1.42–3.72)	N/A
	P-value	0.001	N/A
Adjuvant therapy	n (%)	N/A	12 (5)	N/A	N/A	N/A	N/A	N/A	N/A
	mean ± SD		N/A
	P-value		0.23
	OR (95% CI)	0.71 (0.44–1.15)	N/A			0.54 (0.18–1.62)
	P-value	0.17				0.27
Postoperative pancreatic fistula	n (%)	N/A	1 (0.4)	6 (5)	9 (8)	N/A	4 (3)	N/A	N/A
	mean ± SD		N/A	N/A	N/A		N/A
	P-value		0.71	0.22	0.008		0.036
	OR (95% CI)	2.32 (1.29–4.18)	N/A	N/A	N/A	N/A	N/A
	P-value	0.005	N/A	N/A	N/A	N/A	N/A
Pneumobilia	n (%)	N/A	N/A	15 (11)	19 (17)	N/A	N/A	N/A	N/A
	mean ± SD			N/A	N/A
	P-value			0.17	0.012
	OR (95% CI)			N/A	28.8 (2.32–358)
	P-value				0.009
Delayed gastric emptying	n (%)	N/A	N/A	0	5 (4)	N/A	N/A	N/A	N/A
	mean ± SD			N/A	N/A
	P-value			0.20	0.22
	OR (95% CI)			N/A	N/A
	P-value			N/A	N/A
Postoperative alkaline phosphatase	n (%)	N/A	N/A	20 (15)	15 (13)	N/A	N/A	N/A	N/A
	mean ± SD			N/A	N/A
	P-value			0.003	0.003
	OR (95% CI)			3.81 (1.52–9.55)	6.03 (1.36–6.81)
	P-value			0.004	0.018

Statistically significant results are displayed in bold

^aPylorus preserving pancreatoduodenectomy vs pylorus resecting pancreatoduodenectomy

^bMedian (range)