Fig. 7.

Correlations between the STAT1 responses to manganese/flavonoids combinations and the STAT1 or Nrf2 responses to flavonoids alone in BV-2 microglia. Sixty four flavonoids were presented to cells at 50 μM in all experiments, Mn(II) - at 100 μM (the upper row) or at 200 μM (the lower row). The activation folds (a.f.) are luciferase activities in flavonoid-only treated cells normalized for the untreated reporter; the relative activation folds (r.a.f.) are luciferase activities in Mn(II)/flavonoid-treated cells normalized for the Mn(II)-only treated reporter