Table 2.
Acronym, title, principal investigators (PI), recruitment status, and important publications of DZHK studies
| Acronym | Title | PI | Recruitment |
|---|---|---|---|
| TORCH-DZHK1 | Translational registry for cardiomyopathies (R) [7, 8] | Prof. Dr. Hugo A. Katus, Prof. Dr. Wolfgang Hoffmann | Completed |
| TransitionCHF-DZHK2 | Systolic dysfunction to congestive heart failure cohort study (C) | Prof. Dr. Gerd Hasenfuß, Prof. Dr. med. Rolf Wachter, Prof. Dr. Frank Edelmann | Ongoing |
| VAD-DZHK3 | Early versus emergency left ventricular assist device implantation in patients awaiting cardiac transplantation (CS) | Prof. Dr. Volkmar Falk, Prof. Dr. Christoph Knosalla, Prof. Dr. Gerd Hasenfuß, Prof. Dr. Tim Friede | Ongoing |
| TOMAHAWK-DZHK4 | Immediate unselected coronary angiography versus delayed triage in survivors of out-of-hospital cardiac arrest without ST-segment elevation (CS) [9–11] | Prof. Dr. Steffen Desch, Prof. Dr. Holger Thiele | |
| FAIR-HF2-DZHK5 | Intravenous iron in patients with systolic heart failure and iron deficiency to improve morbidity and mortality (CS) [10, 11] | Prof. Dr. Dr. Mahir Karakas, Prof. Dr. Stefan Anker | Ongoing |
| DEDICATE-DZHK6 | Randomized Trial of TAVI versus SAVR in Patients with Symptomatic Severe Aortic Valve Stenosis and Intermediate Risk of Mortality (CS) [12] | Prof. Dr. Stefan Blankenberg, PD Dr. Moritz Seiffert | Completed, follow-up continuing |
| APPROACH-ACS-AF-DZHK7 | Apixaban versus Phenprocoumon: oral anticoagulation plus antiplatelet therapy in patients with acute coronary syndrome and atrial fibrillation (CS) | Prof. Dr. med. Reza Wakili, Prof. Dr. Steffen Massberg | Completed |
| SPIRIT-HF-DZHK8 | SPIRonolactone In the Treatment for Heart Failure (CS) | Prof. Dr. Frank Edelmann | Ongoing |
| SMART-MI-DZHK9 | Implantable cardiac monitors in high-risk post-infarction patients with cardiac autonomic dysfunction (CS) [13–16] | Prof. Dr. Stefan Kääb, Prof. Dr. Steffen Massberg | Completed |
| CAVA-ADHF-DZHK10 | Ultrasound evaluation of the inferior vena cava in addition to clinical assessment to guide decongestion in acute decompensated heart failure: a pilot study (CS) [17] | PD Dr. med. Alexander Jobs, Prof. Dr. Holger Thiele | Completed |
| Ex-VAD-DZHK11 | Exercise Training in Patients with Left Ventricular Assist Device (CS) [18] | Prof. Dr. Frank Edelmann, Prof. Dr. Volkmar Falk, Martin Halle | Completed |
| Decipher HFpEF-DZHK12 | Validation of Cardiovascular Magnetic Resonance against Invasive Haemodynamics in Patients with Heart Failure with Preserved Ejection Fraction (CS) | Prof. Dr. Eike Nagel | Ongoing |
| CTSN-TVR-DZHK14 | Evaluating the benefit of concurrent tricuspid valve repair during mitral surgery (CS) [19] | Prof. Dr. Volkmar Falk, Annetine C. Gelijns | Completed, follow-up ongoing |
| SCREEN AF-DZHK15 | Home-Based Screening for Early Detection of Atrial Fibrillation in Primary Care Patients Aged 75 Years and Older (CS) [20] | Prof. Dr. med. Rolf Wachter, David Gladstone, Prof. Jeff Healey | Completed, follow-up ongoing |
| CLOSURE-AF-DZHK16 | Left atrial appendage CLOSURE in patients with Atrial Fibrillation at high risk of stroke and bleeding compared to medical therapy (CS) [21–24] | Prof. Dr. Ulf Landmesser, Prof. Dr. Ingo Eitel, Prof. Dr. med. Leif-Hendrik Boldt | |
| HFpEF-stress-DZHK17 | Cardiovascular magnetic resonance real time exercise stress testing in heart failure with preserved ejection fraction (CS) [25–28] | Prof. Dr. Dr. med. Andreas Schuster | Completed |
| METRIS-HF-DZHK18 | Effect of Metformin in insulin resistant patients with heart failure with reduced ejection fraction (CS) | Prof. Dr. Dr. Wolfram Döhner, Prof. Dr. Tim Friede | Ongoing |
| PRAISE-DZHK19 I DZNEB001 | Prediction of Acute Coronary Syndrome in Acute Ischemic Stroke (CS) | Prof. Dr. Matthias Endres, Prof. Dr. Ulf Landmesser, Prof. Christian Nolte | Completed |
| BioVAT-HF-DZHK20 | Safety and Efficacy of Induced Pluripotent Stem Cell-derived Engineered Human Myocardium as Biological Ventricular Assist Tissue in Terminal Heart Failure (CS) | Prof. Dr. Wolfram-Hubertus Zimmermann, Prof. Dr. Tim Seidler, Dr. Ahmad Fawad Jebran | Ongoing |
| TORCH-Plus-DZHK21 | TranslatiOnal Registry for CardiomyopatHies-Plus (R) [7] | Prof. Dr. Benjamin Meder | Ongoing |
| EXAMINE-CAD-DZHK22 | First prospective randomized trial to examine a differential therapeutic response in symptomatic patients with non-obstructive coronary artery disease after coronary physiological testing (CS) | Prof. Dr. Ulf Landmesser, Prof. Dr. med. Barbara Stähli | Ongoing |
| CMR-ICD-DZHK23 | Cardiac Magnetic Resonance guidance of Implantable Cardioverter Defibrillator implantation in non-ischaemic dilated cardiomyopathy (CS) | Prof. Dr. Ingo Eitel | Ongoing |
| TRICI-HF-DZHK24 | Tricuspid Intervention in Heart Failure (CS) | Prof. Dr. med. Jörg Hausleiter, PD Dr. Thomas Stocker, Prof. Dr. Steffen Massberg | Ongoing |
| Reduce-MFA-DZHK25 | Effect of anti-fibrotic therapy on regression of myocardial fibrosis after transcatheter aortic valve implantation (TAVI) in aortic stenosis patients with high fibrotic burden (CS) | Prof. Dr. Miriam Puls, Prof. Dr. med. Elisabeth Zeisberg | Ongoing |
| TRINITY-DZHK26 | A multicenter, randomized, double-blind, placebo-controlled trial evaluating immunosuppressive treatment in patients with chronic virus-negative inflammatory cardiomyopathy (CS) | PD Dr. med. Ulrich Grabmaier, Prof. Dr. Steffen Massberg | Planned |
| CABA-HFpEF-DZHK27 | Catheter-based ablation of atrial fibrillation vs. conventional treatment in patients with heart failure with preserved ejection fraction (CS) | Dr. med. Abdul-Shokor Parwani | Planned |
| GECT-DZHK28 | A first-in-human feasibility study to evaluate the safety (and short term effectiveness) of the autologous GrOwnValve transcatheter pulmonary heart valve CS) | PD Dr. Boris Schmitt | Planned |
CS clinical study, C cohort, R registries