Table 3.

Demographics, radiographic findings, histologic diagnoses and clinical outcomes of reported cases of sclerosing odontogenic carcinoma

	Demographics			Radiographic findings	Histologic diagnosis				Clinical
Pub	Age	Sex	Tumor site	Radiology	Initial diagnosis	Second sample	Third sample	Final excision	Definitive management	Recurrence/Management	F/u (mos)
Current case	55	M	Left maxilla	Large, well-defined low-density bony lesion with scalloped borders; external root resorption of adjacent teeth	SOC	N/A	N/A	SOC	Left infrastructure maxillectomy	(−)	19
Seyiti et al. [2]	54	F	Right mandibular body to left mandibular ramus	Irregular, extensive lytic changes with ill-defined borders and patchy calcifications. Buccal and lingual cortices with irregular resorption	Garrè’s osteomyelitis	SOC	N/A	SOC	Mandibulectomy	Not reported	Not reported
Todorovic et al. [3]	62	M	Left maxilla	Infiltrating lesion concerning for malignancy	Benign fibrosseous lesion	SOC	N/A	SOC	Resection	Recurrence at 5 months; 66 Gy in 33 fractions	19
Hanisch et al. [4]	60	M	Left mandible	Ill-defined lytic osseous changes with expansion, erosion, and perforation, highly suspicious of a malignant tumor	No signs of a neoplastic process	Low-grade squamous cell carcinoma	N/A	SOC	1. Left hemi-mandibulectomy 2. Radical ipsilateral neck dissection	(−)	9
Wood et al. [1]	43	F	Right anterior hard palate	12 mm × 4.3 mm × 5.1 mm enhancing soft tissue mass with no evidence of bone destruction	Adenocarcinoma NOS	N/A	N/A	SOC	Right maxillectomy with wide margins	(−)	17
Tan et al. [5]	31	F	Right mandible	Well-circumscribed round radiolucent lesion measuring 1 cm, with scattered specks of radiopacities and a distinct sclerotic peripheral margin	SOC	N/A	N/A	N/A	Excisional biopsy by enucleation	(−)	12
Hussain et al. [6]	54	M	Right maxilla	Well demarcated radiolucency related to the upper right lateral incisor and canine teeth with loss of the lamina dura around the roots and irregular resorption of the canine	Poorly differentiated squamous cell carcinoma (metastatic). Revised to odontogenic carcinoma	N/A	N/A	SOC	Resection with 5 mm margins	(−)	19
Saxena et al. [7]	42	M	Left mandible	Well-defined unilocular lytic lesion in the left anterior region of the mandible with a smooth outline and no sclerotic margins. Perforation of buccal and lingual cortices	Epithelium-rich variant of central odontogenic fibroma	Primary intraosseous carcinoma of odontogenic origin	N/A	SOC	1. Hemi-mandibulectomy 2. Radical neck dissection 3. Postoperative radiotherapy	(−)	10
Irie et al. [8]	67	M	Left mandible	Mixed well and ill-defined radiolucency without definite root resorption, focally expansile with thinning and perforation of buccal cortex	Compatible with benign fibrosseous lesion	BFOL with hyperplastic and metaplastic odontogenic epithelia	Atypical odontogenic epithelium w/ fibrous component	SOC with BFOL	1. Left segmental mandibulectomy 2. Postoperative chemotherapy	(−)	15
Koutlas et al. [9]	72	M	Left mandible	Unavailable	Unavailable	N/A	N/A	SOC	1. Extensive surgery 2. Ipsilateral neck dissection	(−)	5
Koutlas et al. [9]	46	F	Right mandible	Poorly defined osteolytic process with perforation of the buccal cortical plate and thinning of the lingual cortical bone	Unavailable	N/A	N/A	SOC	Extensive surgery	(−)	12
Koutlas et al. [9]	73	F	Right maxilla	Diffuse radiolucency that filled the alveolar ridge and extended into sinus	Poorly differentiated squamous cell carcinoma	N/A	N/A	SOC	1. Extensive surgery 2. Postoperative radiation	(−)	42

N/A not applicable