Table 2.
Treatments used before and after baricitinib initiation, efficacy and adverse events
| NO | Previous treatments | Treatments before baricitinib initiation | Treatments after baricitinib initiation | Follow-up (months) | Clinical evaluation | CR and PR time with baricitinib (months) | Present pred dose (mg/day) | Present treatments | Adverse events |
|---|---|---|---|---|---|---|---|---|---|
| 1 | GC, DEX, MTX, TCZ | Methylprednisolone pulse 500 mg QD*3d, PLEX (once every other day*3), IVIG (20 g/d*3d), Pred 70 mg/d + CsA 3 mg/kg/d |
Pred 50 mg/d + CsA 3 mg/kg/d + baricitinib 4 mg/d |
18 | Effective | 3 (CR) | 2.5 |
Pred 2.5 mg/d CsA 1 mg/kg/d + baricitinib 2 mg/d |
N |
| 2 | GC, MTX |
Pred 30 mg/d + MTX 15 mg/W |
Pred 30 mg/d + MTX 15 mg/W + baricitinib 4 mg/d |
8 | Partially effective | 5 (PR) | 10 |
Pred 10 mg/d + MTX 15 mg/W + baricitinib 4 mg/d |
Abnormal lipid parameters |
| 3 | GC, NSAIDs |
Pred 60 mg/d + NSAIDs |
Pred 50 mg/d + NSAIDs + baricitinib 4 mg/d |
12 | Effective | 2 (CR) | 5 |
Pred 5 mg/d + baricitinib 4 mg/d |
Abnormal lipid parameters |
| 4 | GC, MTX, HCQ, AZA |
AZA 100 mg/d + NSAIDs |
Pred 30 mg/d + CsA 3 mg/kg/d + baricitinib 4 mg/d |
16 | Effective | 4 (CR) | 5 |
Pred 5 mg/d + baricitinib 2 mg/d |
N |
| 5 | GC, LEF | Pred 30 mg/d |
Pred 30 mg/d + CsA 2 mg/kg/d + NSAIDs + baricitinib 4 mg/d |
13 | Effective | 1 (CR) | 12.5 |
Pred 12.5 mg/d + CsA 2 mg/kg/d + baricitinib 4 mg/d |
N |
| 6 | GC, MTX |
Pred 10 mg/d + MTX 15 mg/W |
Pred 10 mg/d + MTX 15 mg/W + baricitinib 4 mg/d |
15 | Effective | 4 (CR) | 0 |
MTX 15 mg/W + baricitinib 2 mg/d |
N |
| 7 | GC, DEX, CsA |
Methylprednisolone pulse 500 mg QD*3d, PLEX (once every other day*3) Pred 60 mg/d + CsA 3 mg/kg/d, IVIG (20 g/d*3d) |
Pred 50 mg/d + CsA 5 mg/kg/d + baricitinib 4 mg/d |
2 | Ineffective |
N (treatments after baricitinib were stopped: Pred + VP16 + ruxolitinib + CsA) |
17.5 |
Pred 17.5 mg/d + ruxolitinib 20 mg/d + CsA 2 mg/kg/d |
Leukopenia, abnormal lipid parameters |
AZA azathioprine, CR complete remission, CsA cyclosporine A, DEX dexamethasone, GC glucocorticoids, HCQ hydroxychloroquine, IVIG intravenous immunoglobulin, LEF leflunomide, MTX methotrexate, NSAIDs nonsteroidal anti-inflammatory drugs, PLEX plasma exchange, PR partial remission, Pred prednisone, QD every day, TCZ tocilizumab, VP16 etoposide