Table 2.
Data and comparisons of lymphatic vascular density (LVD) (assessed by podoplanin immunostaining) in normal oral mucosa and in oral squamous cell carcinoma (OSCC)
| Normal oral mucosa (n = 15) |
Oral squamous cell carcinoma (OSCC) (n = 150) |
p valueb | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Min | p25 | p50 | p75 | Max | Min | p25 | p50 | p75 | Max | 0.01* |
| 4.00 | 6.00 | 7.00 | 7.00 | 11.00 | 1.00 | 6.00 | 9.00 | 12.00 | 26.00 | |
| Normal oral mucosa (n = 15) |
OSCC with low-intensity or no tumor budding (n = 67) | p valuec | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Min | p25 | p50 | p75 | Max | Min | p25 | p50 | p75 | Max | 0.06 |
| 4.00 | 6.00 | 7.00 | 7.00 | 11.00 | 1.00 | 6.00 | 8.00 | 10.00 | 24.00 | |
| Normal oral mucosa (n = 15) |
OSCC with high-intensity tumor buddinga (n = 83) |
p valued | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Min | p25 | p50 | p75 | Max | Min | p25 | p50 | p75 | Max | 0.00* |
| 4.00 | 6.00 | 7.00 | 7.00 | 11.00 | 2.00 | 6.00 | 9.00 | 14.00 | 26.00 | |
| OSCC with low-intensity or no tumor budding (n = 67) |
OSCC with high-intensity tumor buddinga (n = 83) |
p valuee | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Min | p25 | p50 | p75 | Max | Min | p25 | p50 | p75 | Max | 0.04* |
| 1.00 | 6.00 | 8.00 | 10.00 | 24.00 | 2.00 | 6.00 | 9.00 | 14.00 | 26.00 | |
| Tumor budding area in OSCC with high-intensity tumor budding (n = 83) |
Area outside the tumor budding in OSCC with high-intensity tumor budding (n = 83) |
p valuef | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Min | p25 | p50 | p75 | Max | Min | p25 | p50 | p75 | Max | 0.13 |
| 1.00 | 4.00 | 7.00 | 10.00 | 26.00 | 2.00 | 5.00 | 8.00 | 12.00 | 26.00 | |
Min. minimum value, p25 25th percentile, p50 50th percentile (median), p75 75th percentile, Max. maximum value
*Statistically significant p value (p < 0.05)
aThe highest value of LVD of each sample was used in this evaluation (accessed in the tumor budding area or in the area outside the tumor budding)
bThe p value was obtained with the Mann–Whitney test for normal oral mucosa versus oral squamous cell carcinoma (OSCC)
cThe p value was obtained with the Mann–Whitney test for normal oral mucosa versus OSCC with low-intensity or no tumor budding
dThe p value was obtained with the Mann–Whitney test for normal oral mucosa versus OSCC with high-intensity tumor budding
eThe p value was obtained with the Mann–Whitney test for OSCC with low-intensity or no tumor budding versus OSCC with high-intensity tumor budding
fThe p value was obtained with the Wilcoxon test for the tumor budding area in OSCC with high-intensity tumor budding versus the area outside the tumor budding in OSCC with high-intensity tumor budding