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. 2023 Jun 25;19:17448069231185232. doi: 10.1177/17448069231185232

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© The Author(s) 2023

This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure 9. — IL‐6 expression under the effect of propofol with or without PTEN inhibitor bpV. Propofol downregulates inflammatory cytokine IL‐6 protein expression in CPIP mice. (a) and (b) Western blotting shows protein bands (from top) of interleukin 6 (IL‐6) and glyceraldehyde-3‐phosphate dehydrogenase (GAPDH) expression of 24 and 37kDa respectively. Bar chart showing (c) and (d) IL‐6 total protein. Each bar represents mean ± SEM of number of 4 mice after GADPH normalization or Na/K‐ATPase normalization for IL‐6. Two‐way ANOVA with Tukey post multiple comparisons was performed with GraphPad Prism V7.04 software among Sham (mice without CPIP and treatment), CPIP (mice with CPIP induction), C+P (CPIP mice treated with propofol in intralipid) and C+IL (mice injected with intralipid vehicle). Statistical significances were indicated as * with p value ≤ 0.05; **≤ 0.01; ***≤ 0.001 and ****≤ 0.0001 with Sham as reference in (c) and CPIP no inhibitor as reference in (d).