Table 2.
Multivariable Cox regression analysis of recurrence and OS in patients with high- or low-risk MVI
| Variable | High-risk MVI |
Low-risk MVI |
||||||
|---|---|---|---|---|---|---|---|---|
| Recurrence |
OS |
Recurrence |
OS |
|||||
| HR (95% CI) | P | HR (95% CI) | P | HR (95% CI) | P | HR (95% CI) | P | |
| Before PSM | ||||||||
| HBV-DNA level, ≥2,000 vs <2,000 IU/mL | 2.05 (1.41–2.99) | <0.001 | 2.13 (1.34–3.39) | 0.001 | 2.02 (1.59–2.58) | <0.001 | 1.96 (1.45–2.65) | <0.001 |
| ALB, ≥3.5 vs <3.5 g/dL | 0.35 (0.18–0.66) | 0.001 | ||||||
| AFP, >400 vs ≤400 µg/L | 1.73 (1.27–2.37) | <0.001 | 1.94 (1.34–2.82) | 0.001 | – | – | – | – |
| Tumor diameter (I)a, cm | – | – | – | – | 1.51 (1.35–1.71) | <0.001 | 1.39 (1.20–1.60) | <0.001 |
| Tumor number (I), multiple vs solitary | – | – | – | – | 2.10 (1.42–3.09) | <0.001 | 2.01 (1.26–3.21) | 0.003 |
| Tumor capsule (I), incomplete vs complete | – | – | – | – | 1.71 (1.33–2.21) | <0.001 | 1.80 (1.32–2.45) | <0.001 |
| Type of treatment, LT vs LR | 0.19 (0.09–0.36) | <0.001 | 0.10 (0.03–0.28) | <0.001 | 0.37 (0.21–0.65) | <0.001 | 0.34 (0.16–0.70) | 0.003 |
| After PSM | ||||||||
| HBV-DNA level, 2,000 ≥ vs <2,000 IU/mL | 2.41 (1.38–4.22) | 0.002 | 2.88 (1.35–6.13) | 0.006 | 2.07 (1.41–3.04) | <0.001 | 2.07 (1.28–3.35) | 0.003 |
| Child–Pugh grade, B7 vs A | 1.77 (1.00–3.13) | 0.048 | ||||||
| AFP, >400 vs ≤400 µg/L | 1.71 (1.02–2.89) | 0.041 | 2.35 (1.19–4.65) | 0.014 | – | – | – | – |
| Tumor diameter (I), cm | 1.37 (1.14–1.65) | 0.001 | 0.29 (1.03–1.62) | 0.024 | ||||
| Tumor number (I)a, multiple vs solitary | – | – | – | – | 2.33 (1.46–3.71) | <0.001 | 2.23 (1.28–3.88) | 0.005 |
| Tumor capsule (I), incomplete vs complete | 1.58 (1.05–2.36) | 0.026 | 1.74 (1.07–2.82) | 0.024 | ||||
| Type of treatment, LT vs LR | 0.18 (0.09–0.37) | <0.001 | 0.12 (0.04–0.37) | <0.001 | 0.37 (0.21–0.66) | 0.001 | 0.36 (0.17–0.78) | 0.009 |
OS, overall survival; MVI, microvascular invasion; PSM, propensity score matching; HBV-DNA, hepatitis B virus-deoxyribonucleic acid; AFP, alpha fetoprotein; LT, liver transplantation; LR, liver resection; HR, hazard ratio; CI, confidence interval.
a
(I) was based on preoperative imaging studies.