TABLE 1.
The details of the top 30 hub genes.
| No. | Gene symbol | Full name | Function |
|---|---|---|---|
| 1 | ASPM | assembly factor for spindle microtubules | This gene is essential for normal mitotic spindle function in embryonic neuroblasts |
| 2 | NUSAP1 | nucleolar and spindle associated protein | NUSAP1 is a nucleolar-spindle-associated protein that plays a role in spindle microtubule organization |
| 3 | KIF11 | kinesin family member 11 | This gene encodes a motor protein that belongs to the kinesin-like protein family which are known to be involved in various kinds of spindle dynamics |
| 4 | TOP2A | DNA topoisomerase II alpha | This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription |
| 5 | CCNA2 | cyclin A2 | The protein encoded by this gene belongs to the highly conserved cyclin family, whose members function as regulators of the cell cycle |
| 6 | MAD2L1 | mitotic arrest deficient 2 like 1 | MAD2L1 is a component of the mitotic spindle assembly checkpoint that prevents the onset of anaphase |
| 7 | BUB1B | BUB1 mitotic checkpoint serine/threonine kinase B | This gene encodes a kinase involved in spindle checkpoint function |
| 8 | CDK1 | cyclin dependent kinase 1 | The protein encoded by this gene is a member of the Ser/Thr protein kinase family which is essential for G1/S and G2/M phase transitions of eukaryotic cell cycle |
| 9 | CDC20 | cell division cycle 20 | CDC20 appears to act as a regulatory protein interacting with several other proteins at multiple points in the cell cycle |
| 10 | CCNB1 | cyclin B1 | The protein encoded by this gene is a regulatory protein involved in mitosis |
| 11 | CCNB2 | cyclin B2 | Cyclin B2 is a member of the cyclin family which are essential components of the cell cycle regulatory machinery |
| 12 | CDK2 | cyclin dependent kinase 2 | This gene encodes a member of a family of serine/threonine protein kinases that participate in cell cycle regulation |
| 13 | CENPE | centromere protein E | Centrosome-associated protein E (CENPE) is a kinesin-like motor protein that accumulates in the G2 phase of the cell cycle |
| 14 | MAD1L1 | mitotic arrest deficient 1 like 1 | MAD1L1 is a component of the mitotic spindle-assembly checkpoint and may play a role in cell cycle control and tumor suppression |
| 15 | BUB1 | BUB1 mitotic checkpoint serine/threonine kinase | This gene encodes a serine/threonine-protein kinase that play a central role in mitosis and also plays a role in inhibiting the activation of the anaphase promoting complex/cyclosome |
| 16 | CENPF | centromere protein F | This gene encodes a protein that associates with the centromere-kinetochore complex.It play a role in chromosome segregation during mitotis |
| 17 | MKI67 | marker of proliferation Ki-67 | Enables protein C-terminus binding activity. Involved in regulation of chromosome segregation and regulation of mitotic nuclear division |
| 18 | CCNF | cyclin F | This gene encodes a member of the cyclin family. Cyclins are important regulators of cell cycle transitions |
| 19 | CKS2 | CDC28 protein kinase regulatory subunit 2 | CKS2 protein binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function |
| 20 | PKMYT1 | protein kinase, membrane associated tyrosine/threonine 1 | This gene encodes a member of the serine/threonine protein kinase family. The encoded protein is a membrane-associated kinase |
| 21 | KIF23 | kinesin family member 23 | The protein encoded by this gene is a member of kinesin-like protein family |
| 22 | NDC80 | NDC80 kinetochore complex component | This gene encodes a component of the NDC80 kinetochore complex. This protein functions to organize and stabilize microtubule-kinetochore interactions |
| 23 | FOXM1 | forkhead box M1 | The protein encoded by this gene is a transcriptional activator involved in cell proliferation |
| 24 | ZWINT | ZW10 interacting kinetochore protein | This gene encodes a protein that is clearly involved in kinetochore function |
| 25 | HMMR | hyaluronan mediated motility receptor | The protein encoded by this gene is involved in cell motility. It is expressed in breast tissue |
| 26 | GTSE1 | G2 and S-phase expressed 1 | The protein encoded by this gene is only expressed in the S and G2 phases of the cell cycle.The encoded protein binds the tumor suppressor protein p53, repressing its ability to induce apoptosis |
| 27 | MELK | maternal embryonic leucine zipper kinase | Enables calcium ion binding activity.Involved in apoptotic process; cell population proliferation; and protein autophosphorylation |
| 28 | DLGAP5 | DLG associated protein 5 | Enable microtubule binding activity. Involved in several processes, including centrosome localization; kinetochore assembly; and mitotic spindle organization |
| 29 | SPC25 | SPC25 component of NDC80 kinetochore complex | This gene encodes a protein that involved in kinetochore-microtubule interaction and spindle checkpoint activity |
| 30 | KIF20A | kinesin family member 20A | Enables protein kinase binding activity. Involved in microtubule bundle formation; midbody abscission; and regulation of cytokinesis |