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. 2023 Jun 13;17:1097067. doi: 10.3389/fnins.2023.1097067

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Copyright © 2023 Wu and Feng.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Schematic diagram of hypothesized pathway of the effects of MT on mental and physical wellbeing and aging. NF-kB-Nuclear Factor kappa B; IL-6-Interleukin-6; TNF-α-Tumor Necrosis Factor-alpha; PGE-2-prostaglandin E2; ROS-Reactive Oxygen Species. Stress activates the HPV axis, releasing cortisol, and increased cortisol and oxidative stress lead to increased stress. MT can prevent and treat ND by promoting telomerase activity, thereby lengthening telomeres and slowing aging, and by promoting DNA methylation associated with ND and reducing neuroinflammation (By Figdraw).