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. 2023 May 30;38(25):e202. doi: 10.3346/jkms.2023.38.e202

Table 3. HRs (95% CIs) of fimasartan for clinical outcomes compared to other ARBs or valsartan.

Clinical outcomes of fimasartan Number of cases Incidence rate (per 1,000 person-years) Unadjusted Adjusted
HR (95% CI) P value HR (95% CI) P value
A composite outcomea 16 63.6
Versus other ARBs 0.68 (0.37–1.24) 0.21 0.82 (0.46–1.45) 0.489
Versus valsartan 0.74 (0.37–1.45) 0.36 0.84 (0.45–1.57) 0.593
All-cause death 6 22.4
Versus other ARBs 0.50 (0.22–1.12) 0.09 0.70 (0.30–1.63) 0.412
Versus valsartan 0.61 (0.25–1.49) 0.28 0.86 (0.32–2.28) 0.764
Recurrent myocardial infarction 5 19.4
Versus other ARBs 1.30 (0.50–3.35) 0.59 1.28 (0.49–3.34) 0.614
Versus valsartan 1.18 (0.44–3.19) 0.75 1.24 (0.43–3.61) 0.690
Hospitalization for heart failure 5 18.9
Versus other ARBs 0.62 (0.21–1.79) 0.37 0.70 (0.27–1.84) 0.471
Versus valsartan 0.58 (0.18–1.88) 0.36 0.61 (0.20–1.82) 0.373
Stroke 2 7.5
Versus other ARBs 0.47 (0.13–1.61) 0.23 0.59 (0.18–1.96) 0.393
Versus valsartan 0.46 (0.13–1.64) 0.23 0.49 (0.13–1.81) 0.278

HRs were adjusted for age, sex, previous revascularization, previous ARB or angiotensin-converting enzyme inhibitor therapy, diabetes mellitus, hypertension, hyperlipidemia, atrial fibrillation of flutter, chronic obstructive pulmonary disease, peripheral artery disease, malignancy, admission at tertiary hospital, and discharge medications.

ARB = angiotensin II receptor blocker, CI = confidence interval, HR = hazard ratio.

aA composite of all-cause death, recurrent myocardial infarction, hospitalization for heart failure, and stroke.