Table 3. HRs (95% CIs) of fimasartan for clinical outcomes compared to other ARBs or valsartan.
| Clinical outcomes of fimasartan | Number of cases | Incidence rate (per 1,000 person-years) | Unadjusted | Adjusted | |||
|---|---|---|---|---|---|---|---|
| HR (95% CI) | P value | HR (95% CI) | P value | ||||
| A composite outcomea | 16 | 63.6 | |||||
| Versus other ARBs | 0.68 (0.37–1.24) | 0.21 | 0.82 (0.46–1.45) | 0.489 | |||
| Versus valsartan | 0.74 (0.37–1.45) | 0.36 | 0.84 (0.45–1.57) | 0.593 | |||
| All-cause death | 6 | 22.4 | |||||
| Versus other ARBs | 0.50 (0.22–1.12) | 0.09 | 0.70 (0.30–1.63) | 0.412 | |||
| Versus valsartan | 0.61 (0.25–1.49) | 0.28 | 0.86 (0.32–2.28) | 0.764 | |||
| Recurrent myocardial infarction | 5 | 19.4 | |||||
| Versus other ARBs | 1.30 (0.50–3.35) | 0.59 | 1.28 (0.49–3.34) | 0.614 | |||
| Versus valsartan | 1.18 (0.44–3.19) | 0.75 | 1.24 (0.43–3.61) | 0.690 | |||
| Hospitalization for heart failure | 5 | 18.9 | |||||
| Versus other ARBs | 0.62 (0.21–1.79) | 0.37 | 0.70 (0.27–1.84) | 0.471 | |||
| Versus valsartan | 0.58 (0.18–1.88) | 0.36 | 0.61 (0.20–1.82) | 0.373 | |||
| Stroke | 2 | 7.5 | |||||
| Versus other ARBs | 0.47 (0.13–1.61) | 0.23 | 0.59 (0.18–1.96) | 0.393 | |||
| Versus valsartan | 0.46 (0.13–1.64) | 0.23 | 0.49 (0.13–1.81) | 0.278 | |||
HRs were adjusted for age, sex, previous revascularization, previous ARB or angiotensin-converting enzyme inhibitor therapy, diabetes mellitus, hypertension, hyperlipidemia, atrial fibrillation of flutter, chronic obstructive pulmonary disease, peripheral artery disease, malignancy, admission at tertiary hospital, and discharge medications.
ARB = angiotensin II receptor blocker, CI = confidence interval, HR = hazard ratio.
aA composite of all-cause death, recurrent myocardial infarction, hospitalization for heart failure, and stroke.