Table 6.

The regulatory role of MicroRNAs in MIRI.

MicroRNAs	Species	Expression	Targeted genes	Mechanism	Refs.
miR-1	rat	↓	Hsp90aa1	Pro-apoptosis	(109)
miR-125a	rat/H9c2	↓	DRAM2	Anti-oxidative stress, Anti-autophagy	(107)
miR-125a-5p	mice	↓	KLF13, TGFBR1, DAAM1	Anti-inflammatory, Anti-apoptosis	(119)
miR-125b	rat	↓	SIRT7	Anti-apoptosis	(113)
miR-126	rat	↑	ERRFI1	Anti-apoptosis	(110)
miR-128	mice/H9c2	↓	Plk2	Anti-apoptosis	(120)
miR-128	rat/H9c2	↓	TXNIP	Anti-oxidative stress, Anti-apoptosis	(121)
miR-128-1-5p	rat/H9c2	↓	Gadd45g	Anti-apoptosis	(122)
miR-129	rat/H9c2	↓	PTEN	Anti-apoptosis	(123)
miR-129	cardiomyocytes	↓	TLR4	Anti-inflammatory	(124)
miR-129-5p	H9c2	↓	TRPM7	Anti-inflammatory, Anti-apoptosis	(125)
miR-129-5p	rat	↑	HMGB1	Anti-apoptosis	(126)
miR-133a	rat/H9c2	↓	ELAVL1	Anti-pyroptosis	(116)
miR-133a	rat/H9c2	↓	IGF1R	Anti-apoptosis	(115)
miR-135b-3p	rat/H9c2	↑	GPX4	Pro-Ferroptosis	(108)
miR-138	mice	↓	EGR1	Anti-inflammatory	(127)
miR-138-5p	mice	↓	Ltb4r1	Anti-inflammatory	(128)
miR-140	mice	↓	YES1	Anti-apoptosis	(129)
miR-140-3p	H9c2	↓	PTEN	Anti-oxidative stress, Anti-apoptosis	(111)
miR-15b-5p	rat/H9c2	↑	Sirt3	Anti-pyroptosis	(117)
miR-155-5p	mice	↑	JAK2/STAT1	Pro-inflammation	(130)
miR-155-5p	mice	↑	NEDD4	Pro-apoptosis	(131)
miR-181a-5p	cardiomyocytes	↑	ADCY1	Pro-pyroptosis	(132)
miR-182-5p	rat/H9c2	↑	STK17A	Pro-oxidative stress	(133)
miR-21	mice	↓	SPP1	Anti-oxidative stress, Anti-inflammatory, Anti-apoptosis	(134)
miR-214-5p	mice	↓	FASLG	Anti-apoptosis	(112)
miR-24	rat/H9c2	↑	Keap1	Anti-apoptosis	(114)
miR-29b	rat/H9c2	↓	PTEN	Anti-oxidative stress, Anti-inflammatory, Anti-apoptosis	(118)
miR-29b-3p	rat/H9c2	↓	HMCN1	Anti-oxidative stress, Anti-fibrosis, Anti-apoptosis	(135)
miR-29c	mice	↓	PTEN	Anti-autophagy	(106)
miR-30b	mice	↓	CypD	Anti-necrosis	(136)
miR-486	mice	↓	PTEN, FoxO1	Anti-apoptosis	(137)