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. 2023 Jun 20;120(26):e2301606120. doi: 10.1073/pnas.2301606120

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Copyright © 2023 the Author(s). Published by PNAS.

This open access article is distributed under Creative Commons Attribution-NonCommercial-NoDerivatives License 4.0 (CC BY-NC-ND).

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Fig. 1. — Bioreducible lipophilic PBAE–mRNA nanoparticles (NPs) as cancer vaccine. (A) Schematic of the mRNA-based cancer vaccine technology using polymeric (PBAE) NPs. (B) Reaction scheme for bioreducible lipophilic PBAEs. The bioreducible diacrylate backbone monomer (R) is polymerized with a 1:1 mixture of a hydrophilic amine sidechain monomer (S4) and a lipophilic amine side chain monomer (Sc12-18) via Michael addition. The obtained diacrylate-terminated random copolymer is endcapped with an amine-containing monomer (A–E) to form the final polymer structure. (C) Monomers used in the combinatorial library synthesis to form bioreducible lipophilic PBAEs.