Table 3. Mortality Analysis in 17 726 Individuals With Nonfunctional Adrenal Adenomas Compared With 124 366 Controls, Unadjusted and Adjusted to Age, Sex, and Possible Confoundersa.
| Characteristic | Cases | Controls | Hazard ratio (95% CI) | P value | Adjusted hazard ratio (95% CI) | P value |
|---|---|---|---|---|---|---|
| Overall total mortalityb | 3719 | 19 343 | 1.43 (1.38-1.48) | <.001 | 1.21 (1.16-1.26) | <.001 |
| Mortality due to cancer | 851 | 3719 | 1.63 (1.51-1.76) | <.001 | 1.54 (1.42-1.67) | <.001 |
| Mortality due to CV diseases | 1212 | 6369 | 1.43 (1.34-1.52) | <.001 | 1.21 (1.13-1.29) | <.001 |
| Men | 1522 | 9365 | 1.35 (1.28-1.43) | <.001 | 1.19 (1.11-1.26) | <.001 |
| Women | 2197 | 9978 | 1.52 (1.45-1.59) | <.001 | 1.22 (1.15-1.28) | <.001 |
| Age <65 y | 750 | 2350 | 2.26 (2.07-2.46) | <.001 | 1.44 (1.31-1.58) | <.001 |
| Age >65 y | 2969 | 16 993 | 1.4 (1.34-1.45) | <.001 | 1.15 (1.1-1.2) | <.001 |
| Adrenalectomy | 352 | 124 366 | 0.74 (0.56-0.97) | .03 | 0.95 (0.72-1.24) | .69 |
| No adrenalectomy | 17 374 | 124 366 | 1.45 (1.4-1.5) | <.001 | 1.21 (1.16-1.26) | <.001 |
Abbreviation: CV, cardiovascular.
a
All cases with cancer discovered within the first 3 months after the diagnosis of the nonfunctional adrenal adenoma have been excluded.
b
Overall follow-up period up to 16 years.