Table 1. Baseline Characteristics.
| Characteristic | No. (%) | |
|---|---|---|
| Butylphthalide (n = 607) | Placebo (n = 609) | |
| Age, median (IQR), y | 66 (56-72) | 66 (57-74) |
| Gender | ||
| Men | 412 (67.9) | 415 (68.1) |
| Women | 195 (32.1) | 194 (31.9) |
| Body mass index, median (IQR)a | 24.2 (22.0-26.4) | 24.2 (21.9-26.7) |
| Blood pressure, median (IQR), mm Hg | ||
| Systolic | 149.5 (138.0-163.5) | 150.0 (136.0-163.0) |
| Diastolic | 87.0 (80.0-95.0) | 86.0 (79.0-95.0) |
| Medical history | ||
| Stroke | 138 (22.7) | 133 (21.8) |
| Hypertension | 351 (57.8) | 345 (56.7) |
| Hypercholesterolemia | 29.0 (4.8) | 20 (3.3) |
| Diabetes | 131 (21.6) | 113 (18.6) |
| Heart disease | 144 (23.7) | 147 (24.1) |
| mRS score prior to onset | ||
| 0 | 563 (92.8) | 573 (94.1) |
| 1 | 44 (7.2) | 36 (5.9) |
| ASPECTS score, median (IQR) | 9 (8-10) | 9 (8-10) |
| NIHSS score, median (IQR) | 8 (5-12) | 8 (5-12) |
| Stroke category | ||
| Mild (NIHSS score of 4-7) | 262 (43.2) | 283 (46.5) |
| Moderate (NIHSS score of 8-14) | 246 (40.5) | 226 (37.1) |
| Severe (NIHSS score of 15-25) | 99 (16.3) | 100 (16.4) |
| Revascularization treatment, No./total No. (%) | ||
| Intravenous rt-PA treatment | 417/601 (69.4) | 420/604 (69.5) |
| Endovascular treatment or bridging | 184/601 (30.6) | 184/604 (30.5) |
| Successful reperfusionb,c | 160 (87.0) | 168 (91.3) |
| Clot locationc | ||
| Internal carotid artery | 41 (22.3) | 47 (25.5) |
| Middle cerebral artery | 110 (59.8) | 115 (62.5) |
| Anterior cerebral artery | 3 (1.6) | 1 (0.5) |
| Vertebral artery | 7 (3.8) | 4 (2.2) |
| Posterior cerebral artery | 4 (2.2) | 0 |
| Basilar artery | 19 (10.3) | 17 (9.2) |
| Onset to drug administration, median (IQR), min | 254 (203-310) | 261 (209-310) |
| OCSP subtype | ||
| TACI | 171 (28.2) | 166 (27.3) |
| PACI | 321 (52.9) | 329 (54.0) |
| POCI | 76 (12.5) | 76 (12.5) |
| LACI | 39 (6.4) | 38 (6.2) |
Abbreviations: ASPECTS, Alberta Stroke Program Early Computed Tomography Score; LACI, lacunar infarcts; mRS, modified Rankin Scale; NIHSS, National Institute of Health Stroke Scale; OCSP, Oxfordshire Community Stroke Project; PACI, partial anterior circulation infarcts; POCI, posterior circulation infarcts; rt-PA, recombinant tissue plasminogen activator; TACI, total anterior circulation infarcts.
Calculated as weight in kilograms divided by height in meters squared.
Reperfusion status was evaluated according to the modified Thrombolysis In Cerebral Infarction scale, and successful reperfusion was defined as an modified Thrombolysis In Cerebral Infarction score of 2b to 3.
Data were only available for 368 patients receiving endovascular treatment.