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. 2023 Jun 15;14(6):846–861. doi: 10.4239/wjd.v14.i6.846

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©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.

This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial.

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Differential metabolites and pathways across groups. A and B: A volcano diagram illustrated the distinct metabolite compositions between control vs model (A) and model vs LR-5 (B). Green and red colors represent significant upregulation and downregulation of metabolites, respectively. Significant deferentially expressed metabolites were determined based on a P value < 0.05 and a log2fold-change of at least 2.0; C: XploreMET (Metabo-Profile) was used to evaluate the Kyoto Encyclopedia of Genes and Genomes metabolic pathways of the differential metabolites. FC: Fold change; LR: Lomatogonium rotatum; VIP: Variable importance in projection.