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. Author manuscript; available in PMC: 2023 Jun 27.
Published in final edited form as: Neurobiol Dis. 2021 Jan 9;150:105258. doi: 10.1016/j.nbd.2021.105258

Fig. 9. Distinct roles of caspase-8 in cell fate regulation.

Fig. 9.

As illustrated by the blue triangles at the bottom, different states of the enzymatic or catalytic activities of caspase-8 are critical for the outcome: (A) Enzymatic activity of caspase-8 induces apoptosis (as in RGCs), (B) catalytic activity (in the absence of full proteolytic cleavage) signals towards cell survival (as in astroglia, or z-IETD-fmk-treated RGCs) and (C) no caspase-8 activity induces necroptosis (as in caspase-8-deleted astroglia). Thus, caspase-8 deletion in astroglia changes the state from “B to C”, while the inhibition of caspase-8 cleavage shifts the signal from “A to B” in RGCs.