Table 2.
Odds ratio (OR) and 95% confidence intervals (CI) for the association between selected characteristics of 1st degree relatives and bladder cancer risk among participants
| Characteristics of 1st degree relatives | Cases | Controls | OR* | 95% CI | ||
|---|---|---|---|---|---|---|
| n | % | n | % | |||
| Type of cancer | ||||||
| None | 451 | 37.8 | 611 | 43.1 | Ref. | Ref. |
| Bladder cancer | 56 | 4.7 | 41 | 2.9 | 1.8 | (1.2, 2.9) |
| Other cancer | 686 | 57.5 | 766 | 54.0 | 1.2 | (0.99, 1.4) |
| Number of relatives with any cancer | ||||||
| None | 451 | 37.8 | 611 | 43.1 | Ref. | Ref. |
| 1 family member | 451 | 37.8 | 515 | 36.3 | 1.2 | (0.96, 1.4) |
| ≥ 2 family members | 291 | 24.4 | 292 | 20.6 | 1.3 | (1.03, 1.6) |
| Age at diagnosis of 1st cancer in family member | ||||||
| None | 451 | 37.8 | 611 | 43.1 | Ref. | Ref. |
| ≤ 55 years | 314 | 26.3 | 332 | 23.4 | 1.2 | (0.98, 1.5) |
| > 55 years | 418 | 35.0 | 467 | 32.9 | 1.2 | (0.99, 1.5) |
| Missing age | 10 | 0.8 | 8 | 0.6 | 1.2 | (0.5, 3.4) |
| Specific member with cancer diagnosis | ||||||
| No parent with cancer | 671 | 56.2 | 835 | 58.9 | Ref. | Ref. |
| Parent with bladder cancer | 29 | 2.4 | 27 | 1.9 | 1.3 | (0.7, 2.3) |
| Parent with other cancer | 493 | 41.3 | 556 | 39.2 | 1.1 | (0.93, 1.3) |
| No mother with cancer | 888 | 74.4 | 1072 | 75.6 | Ref. | Ref. |
| Mother with bladder cancer | 9 | 0.8 | 13 | 0.9 | 0.8 | (0.3, 1.9) |
| Mother with other cancer | 296 | 24.8 | 333 | 23.5 | 1.1 | (0.87, 1.3) |
| No father with cancer | 899 | 75.4 | 1097 | 77.4 | Ref. | Ref. |
| Father with bladder cancer | 20 | 1.7 | 14 | 1.0 | 1.8 | (0.8, 3.7) |
| Father with other cancer | 274 | 23.0 | 307 | 21.7 | 1.1 | (0.89, 1.3) |
| No sibling with cancer | 445 | 37.3 | 542 | 38.2 | Ref. | Ref. |
| Sibling with bladder cancer | 27 | 2.3 | 14 | 1.0 | 2.6 | (1.3, 5.3) |
| Sibling with other cancer | 337 | 28.2 | 355 | 25.0 | 1.2 | (0.99, 1.5) |
| No sister with cancer | 695 | 58.3 | 843 | 59.4 | Ref. | Ref. |
| Sister with bladder cancer | 4 | 0.3 | 3 | 0.2 | 1.6 | (0.3, 7.8) |
| Sister with other cancer | 201 | 16.8 | 205 | 14.5 | 1.3 | (1.01, 1.6) |
| No brother with cancer | 727 | 60.9 | 874 | 61.6 | Ref. | Ref. |
| Brother with bladder cancer | 23 | 1.9 | 11 | 0.8 | 2.6 | (1.2, 5.7) |
| Brother with other cancer | 184 | 15.4 | 201 | 14.2 | 1.0 | (0.8, 1.3) |
| No child with cancer | 991 | 83.1 | 1175 | 82.9 | Ref. | Ref. |
| Child with bladder cancer | 2 | 0.2 | 0 | 0.0 | -- | -- |
| Child with other cancer | 59 | 4.9 | 56 | 3.9 | 1.1 | (0.8, 1.7) |
*
Adjusted for state, age group, gender, race/ethnicity, smoking status, high risk occupation, personal history of cancer
**
High risk occupations are those with an odds ratio of at least 1.5 and at least 10 exposed participants