Table 4.
Odds ratio (OR) and 95% confidence intervals (CI) for the association between the 1st degree relatives’ specific cancer site and bladder cancer risk among participants*
| Cancer site of 1st degree relatives† | Cases | Controls | OR | 95% CI | ||
|---|---|---|---|---|---|---|
| n | % | n | % | |||
| None** | 451 | 37.8 | 611 | 43.1 | Ref. | Ref. |
| All sites | 739 | 61.9 | 807 | 56.9 | 1.2 | (1.01, 1.4) |
| Lip, oral cavity, pharynx | 38 | 3.2 | 43 | 3.0 | 0.9 | (0.6, 1.5) |
| Esophagus | 11 | 0.9 | 11 | 0.8 | 1.3 | (0.5, 3.2) |
| Stomach | 61 | 5.1 | 56 | 3.9 | 1.4 | (0.91, 2.1) |
| Colorectal | 131 | 11.0 | 150 | 10.6 | 1.2 | (0.93, 1.7) |
| Liver | 32 | 2.7 | 44 | 3.1 | 0.7 | (0.4, 1.2) |
| Pancreas | 30 | 2.5 | 38 | 2.7 | 1.03 | (0.6, 1.7) |
| Lung, bronchus, and trachea | 164 | 13.7 | 166 | 11.7 | 1.2 | (0.95, 1.6) |
| Bone | 37 | 3.1 | 30 | 2.1 | 1.4 | (0.8, 2.4) |
| Female breast | 152 | 12.7 | 173 | 12.2 | 1.2 | (0.89, 1.5) |
| Uterus | 42 | 3.5 | 33 | 2.3 | 1.9 | (1.1, 3.1) |
| Cervix | 30 | 2.5 | 20 | 1.4 | 1.8 | (0.98, 3.4) |
| Ovary | 31 | 2.6 | 33 | 2.3 | 1.3 | (0.8, 2.3) |
| Prostate | 93 | 7.8 | 116 | 8.2 | 1.1 | (0.8, 1.5) |
| Kidney | 31 | 2.6 | 27 | 1.9 | 1.6 | (0.87, 2.8) |
| Brain | 40 | 3.4 | 43 | 3.0 | 1.3 | (0.8, 2.1) |
| Melanoma | 28 | 2.3 | 23 | 1.6 | 1.9 | (1.02, 3.6) |
| Lymphoma | 40 | 3.4 | 42 | 3.0 | 1.3 | (0.8, 2.1) |
| Leukemia | 31 | 2.6 | 59 | 4.2 | 0.7 | (0.4, 1.1) |
| Other | 82 | 6.9 | 80 | 5.6 | 1.3 | (0.91, 1.9) |
| Tobacco-associated sites*** | 470 | 39.4 | 476 | 33.6 | 1.3 | (1.06, 1.6) |
| Female genital cancers**** | 106 | 8.9 | 94 | 6.6 | 1.5 | (1.1, 2.1) |
Cancer sites included: urinary/bladder (188); lip, oral cavity, pharynx (14X); esophagus (150); stomach (151); colorectal (153–154, 159); liver (155); pancreas (157); larynx (161); lung, bronchus, trachea (162, 164, 165); bone (170); female breast (174, 175); uterus (179, 182); cervix (180); ovary (183); prostate (185); kidney (189); brain (191, 192); melanoma (172); lymphoma (202.0, 202.1, 202.2, 202.8, 202.9); myeloma (203.0, 238.6); and leukemia (204.0, 204.1, 202.4, 204.2, 204.8, 204.9, 205.0, 2070, 207.2, 206.0, 205.1, 205.2, 205.3, 205.8, 205.9, 206.1, 206.2, 206.8, 206.9, 208.0, 203.1, 207.1, 207.8, 208.1, 208.2, 208.8, 208.9).
Adjusted for state, age group, gender, race/ethnicity, smoking status, high risk occupation, personal history of cancer
Reference group includes participant with no cancer in 1st degree relatives
Tobacco-associated cancers Include cancer of the urinary bladder, lip/oral cavity/pharynx, pancreas, larynx, lung/bronchus/trachea, kidney, stomach, colorectal, liver, cervix, acute myeloid leukemia (https://www.cdc.gov/cancer/uscs/public-use/predefined-seer-stat-variables.htm)
All female genital cancers include uterus, cervix, ovary, vagina, vulva, other female genital organs.
High risk occupations are those with an odds ratio of at least 1.5 and at least 10 exposed participants