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. 2023 Jun 13;14:1162370. doi: 10.3389/fphar.2023.1162370

TABLE 4.

GIS score according to the patients’ symptoms.

Variables N (%) Total Epigastric symptoms 189 (13.9) Retrosternal symptoms 433 (31.8) Overlapping symptoms 738 (54.3) p-Value
1.How often have you had the following symptoms
a. Pain in your chest or behind your breastbone? <0.001
- Daily 46(3.4) 0 14(3.2) 32(4.3)
- Often 158(11.6) 0 37(8.5) 121(16.4)
- Sometimes 172(12.7) 0 43(9.9) 129(17.5)
- Never 983(72.3) 189(100) 339(78.3) 455(61.7)
b. Burning sensation in your chest or behind the breastbone <0.001
- Daily 115(8.5) 0 32(7.4) 83(11.3)
- Often 298(21.9) 0 80(18.5) 218(29.6)
- Sometimes 291(21.4) 0 101(23.3) 190(25.8)
- Never 655(48.2) 189(100) 220(50.8) 246(33.4)
c. Regurgitation or acid taste in your mouth? <0.001
- Daily 112(8.2) 0 25(5.8) 87(11.8)
- Often 326(24) 0 81(18.7) 245(33.2)
- Sometimes 360(26.5) 0 122(28.2) 238(32.2)
- Never 561(41.3) 189(100) 205(47.3) 167(22.7)
d. Pain or burning in your upper stomach? <0.001
- Daily 161(11.8) 40(21.2) 0 121(16.4)
- Often 425(31.3) 76(40.2) 0 349(47.4)
- Sometimes 340(25) 73(38.6) 0 267(36.2)
- Never 433(31.9) 0 433(100) 0
e. Sore throat or hoarseness that is related to your heartburn or acid reflux? <0.001
- Daily 52(3.8) 0 11(2.5) 41(5.6)
- Often 161(11.8) 0 39(9) 122(16.6)
- Sometimes 154(11.3) 0 50(11.5) 104(14.1)
- Never 992(73) 189(100) 333(76.9) 470(63.8)
2.How often have you had difficulty getting a good night´s sleep because of your symptoms? <0.001
- Daily 74 (5.4) 9 (4.8) 14 (3.2) 51 (6.9)
- Often 274 (20.1) 35 (18.5) 54 (12.5) 185 (25.1)
- Sometimes 412 (30.3) 52 (27.5) 110 (25.4) 250 (33.9)
- Never 600 (44.1) 93 (49.2) 255 (58.9) 252 (34.1)
3.How often have your symptoms prevented you from eating or drinking any of the foods you like? <0.001
- Daily 95(7.0) 3(1.6) 24(5.5) 68(9.2)
- Often 238(17.5) 29(15.3) 39(9.0) 170(23.0)
- Sometimes 290(21.3) 49(25.9) 70(16.2) 171(23.2)
- Never 737(54.2) 108(57.1) 300(69.3) 329(44.6)
4.How frequently have your symptoms kept you from being fully productive in your job or daily activities? <0.001
- Daily 35(2.6) 2(1.1) 5(1.2) 28(3.8)
- Often 105(7.7) 8(4.2) 16(3.7) 81(11.0)
- Sometimes 122(9.0) 17(9.0) 17(3.9) 88(11.9)
- Never 1098(80.7) 162(85.7) 395(91.2) 541(73.3)
5.How often do you take additional medication other than what the physician told you to take? <0.001
- Daily 93(6.8) 8(4.2) 22(5.1) 63(8.5)
- Often 114(8.4) 21(11.1) 24(5.5) 69(9.3)
- Sometimes 205(15.1) 27(14.3) 51(11.8) 127(17.2)
- Never 948(69.7) 133(70.4) 336(77.6) 479(64.9)
GIS score (median, interquartile range) 31 (26-34) 32 (29-33) 32 (28-34) 26 (20-30) <0.001

*GIS: gastroesophageal reflux disease impact scale.