Table 3.
Aggregated costs (in 2022€) for diagnostic, preventive, and therapeutic procedures. All Women receive intensified surveillance for breast cancer as standard care. Prophylactic surgeries, initial treatment and palliative care are assumed to occur only once at a one-time cost. Follow-up costs are annual costs over 5 and 10 years after cancer diagnosis for ovarian and breast cancer, respectively. All costs are based on the published literature [21]
| Procedure | Costs (in 2022€) |
|---|---|
| Standard care and prophylactic surgeries | |
| Standard care (intensified surveillance for breast cancer) * | 608 |
| PBM § | 9,032 |
| PBSO § | 3,099 |
| PBM + PBSO§ | 12,131 |
| Initial cancer treatment (surgery, drugs, radiotherapy etc.) § | |
| Breast cancer (pT1-pT3) (incl. standard care) | 20,092 |
| After PBM | 14,333 |
| After PBSO | 20,092 |
| After PBM + PBSO | 14,333 |
| Breast cancer (metastatic) (incl. standard care) | 30,623 |
| After PBM | 24,865 |
| After PBSO | 30,623 |
| After PBM + PBSO | 24,865 |
| Ovarian cancer (non-advanced FIGO I-II) (incl. standard care) | 13,666 |
| After PBM | 13,666 |
| After PBSO | 11,280 |
| After PBM and PBSO | 11,280 |
| Ovarian cancer (advanced FIGO III-IV) (incl. standard care) | 35,052 |
| After PBM | 35,052 |
| After PBSO | 32,666 |
| After PBM and PBSO | 32,666 |
| Palliative care costs § | |
| Metastatic/end stage breast cancer | 12,103 |
| Metastatic/end stage ovarian cancer | 12,103 |
| Annual follow-up costs | |
| Breast cancer (incl. Standard care); 10 years of follow up* | |
| pT1 | 595 |
| pT2 | 652 |
| pT3 | 589 |
| pT4 | 686 |
| pT1 after PBM | 443 |
| pT2 after PBM | 500 |
| pT3 after PBM | 437 |
| pT4 after PBM | 534 |
| pT1 after PBSO | 595 |
| pT2 after PBSO | 652 |
| pT3 after PBSO | 589 |
| pT4 after PBSO | 686 |
| pT1 after PBM and PBSO | 443 |
| pT2 after PBM and PBSO | 500 |
| pT3 after PBM and PBSO | 437 |
| pT4 after PBM and PBSO | 534 |
| Ovarian cancer (incl. Standard care); 5 years of follow up* | |
| Non-advanced (FIGO I + II) | 1,356 |
| Advanced (FIGO III + IV) | 2,389 |
| Non-advanced (FIGO I + II) after PBM | 1,052 |
| Advanced (FIGO III + IV) after PBM | 2,085 |
| Non-advanced (FIGO I + II) after PBSO | 1,214 |
| Advanced (FIGO III + IV) after PBSO | 2,246 |
| Non-advanced (FIGO I + II) after PBM and PBSO | 910 |
| Advanced (FIGO III + IV) after PBM and PBSO | 1,942 |
FIGO I-IV: ovarian cancer stage FIGO grade 1–4; incl.: including; PBM: Prophylactic bilateral mastectomy; PBSO: Prophylactic bilateral salpingo-oophorectomy; pT1-4: breast cancer stage grade pT1-pT4
*annual costs
§ one-time costs