Table 4.

AGREE Classification for adverse events in GI endoscopy

Grading	Definition
No adverse event	• A telephone contact with the general practitioner, outpatient clinic, or endoscopy service without any intervention or  • Extended observation of the patient after the procedure, <3 hours, without any intervention
Grade I	Adverse events with any deviation of the standard postprocedural course, without the need for pharmacologic treatment or endoscopic, radiologic, or surgical interventions.  • Presentation at the emergency ward, without any intervention or  • Hospital admission (<24 hours), without any intervention or  • Allowed therapeutic regimens are drugs as antiemetics, antipyretics, analgesics, and electrolytes or  • Allowed diagnostic tests: radiology and laboratory tests
Grade II	• Adverse events requiring pharmacologic treatment with drugs other than those allowed for grade I adverse events (ie, antibiotics, antithrombotics, etc) or  • Blood or blood product transfusions or  • Hospital admission for more than 24 hours
Grade III	Adverse events requiring endoscopic, radiologic, or surgical intervention
Grade IIIa	Endoscopic or radiologic intervention
Grade IIIb	Surgical intervention
Grade IV	Adverse events requiring intensive care unit/critical care unit admission
Grade IVa	Single-organ dysfunction (including dialysis)
Grade IVb	Multiorgan dysfunction
Grade V	Death of the patient