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. 2023 Jun 26;22:149. doi: 10.1186/s12933-023-01890-9

Table 2.

Independent association of triglyceride-glucose index and NT-proBNP categories with incident MACCEs

Base Model† Adjusted Model††
Hazard Ratio (95% CI) P Value Hazard Ratio (95% CI) P Value
NT-proBNP  < 0.001  < 0.001
Tertile 1 1.00 (Reference) 1.00 (Reference)
Tertile 2 1.53 (1.27‒1.86)  < 0.001 1.30 (1.04‒1.63) 0.020
Tertile 3 2.89 (2.41‒3.45)  < 0.001 1.95 (1.50‒2.54)  < 0.001
TyG index, per 1 unit* 1.16 (1.05‒1.27) 0.002 1.18 (1.05‒1.32) 0.004

*Modeled as linear effects

Base model included the TyG index, NT-proBNP, age, and sex

††Adjusted model included base model plus BMI, diagnosis of AMI, history of hypertension, history of dyslipidemia, history of myocardial infarction, history of arrhythmia, SBP, LVEF, eGFR, hs-CRP, LDL-C, smoking status, and in-hospital treatments (PCI, antiplatelet therapy, β-blocker, ACEI or ARB, and statins)

NT-proBNP, N-terminal pro-B-type natriuretic peptide; MACCEs, major adverse cardio-cerebral events; CI, confidence interval; TyG, triglyceride-glucose; BMI, body mass index; AMI, acute myocardial infarction; SBP, systolic blood pressure; LVEF, left ventricular ejection fraction; eGFR, estimated glomerular filtration rate; hs-CRP, high sensitivity C-reactive protein; LDL-C, low-density lipoprotein cholesterol; PCI, percutaneous coronary intervention; ACEI, angiotensin-converting enzyme inhibitor; ARB, angiotensin receptor blocker