Table 3.

Improvement in MACCEs risk prediction by adding the triglyceride-glucose index and NT-proBNP to the clinical model of GRACE score

	tAUC (95% CI)	P Value	NRI (95% CI)	P Value	IDI (95% CI)	P Value
30 Days MACCEs
Short-term GRACE score	0.66 (0.60‒0.73)	Reference	Reference		Reference
Short-term GRACE score + TyG index + NT-proBNP	0.73 (0.68‒0.79)	0.011	0.205 (0.048‒0.305)	< 0.001	0.0026 (0.0001‒0.0059)	0.020
6 Months MACCEs
Long-term GRACE score	0.62 (0.59‒0.66)	Reference	Reference		Reference
Long-term GRACE score + TyG index + NT-proBNP	0.70 (0.67‒0.73)	< 0.001	0.271 (0.210‒0.328)	< 0.001	0.015 (0.010‒0.020)	< 0.001
1 Year MACCEs
Long-term GRACE score	0.60 (0.56‒0.63)	Reference	Reference		Reference
Long-term GRACE score + TyG index + NT-proBNP	0.67 (0.64‒0.70)	< 0.001	0.233 (0.180‒0.285)	< 0.001	0.019 (0.013‒0.025)	< 0.001
5 Years MACCEs
Long-term GRACE score	0.61 (0.59‒0.64)		Reference		Reference
Long-term GRACE score + TyG index + NT-proBNP	0.64 (0.61‒0.66)	0.019	0.104 (0.056‒0.147)	< 0.001	0.025 (0.015‒0.036)	< 0.001

MACCEs, major adverse cardio-cerebral events; NT-proBNP, N-terminal pro-B-type natriuretic peptide; GRACE, The Global Registry of Acute Coronary Events; tAUC, time-dependent area under the receiver operating characteristic curve; CI, confidence interval; NRI, net reclassification improvement index; IDI, integrated discrimination improvement index; TyG, triglyceride-glucose index