Table 3.
Treatment-related adverse events occurring in at least 5% patients
| Events, n (%) | Any grade | ≥ Grade 3 |
|---|---|---|
| Diarrhea | 50 (94.3) | 10 (18.9) |
| Hypertriglyceridemia | 19 (35.8) | 0 |
| Blood creatinine increased | 18 (34.0) | 0 |
| Aspartate aminotransferase increased | 17 (32.1) | 0 |
| Vomiting | 16 (30.2) | 1 (1.9) |
| Hyperuricemia | 13 (24.5) | 0 |
| Alanine aminotransferase increased | 12 (22.6) | 0 |
| Nausea | 11 (20.8) | 0 |
| White blood cell count decreased | 10 (18.9) | 0 |
| Hypercholesterolemia | 10 (18.9) | 0 |
| Oral ulcer | 9 (17.0) | 0 |
| Headache | 7 (13.2) | 0 |
| Urea nitrogen increased | 6 (11.3) | 0 |
| Anemia | 6 (11.3) | 0 |
| Hypokalemia | 5 (9.4) | 0 |
| Rash | 5 (9.4) | 0 |
| Hand-foot syndrome | 5 (9.4) | 1 (1.9) |
| Neutrophil count decreased | 5 (9.4) | 0 |
| Abdominal distension | 4 (7.5) | 0 |
| Blood glucose increased | 4 (7.5) | 0 |
| Paronychia | 3 (5.7) | 0 |
| Dizziness | 3 (5.7) | 0 |
| Stomachache | 3 (5.7) | 0 |
| Appetite decreased | 3 (5.7) | 0 |