Table 5.

Multiple models for PFS and OS based on TTC

	PFS		OS
	HR (95%CI)	P value	HR (95%CI)	P value
TTC a
≤ 33	1 (Reference)		1 (Reference)
34–40	1.18 (0.91–1.52)	0.221	1.57 (1.10–2.23)	0.012
41–49	1.18 (0.90–1.53)	0.227	1.85 (1.31–2.62)	0.001
> 49	1.15 (0.87–1.51)	0.338	1.51 (1.03–2.19)	0.033
TTC b	1.003 (0.997–1.009)	0.333	1.009 (1.002–1.017)	0.011
P for trendc		0.381*		0.031*

Abbreviation: PFS, Progression-free survival; OS, Overall survival; TTC, Time to postoperative adjuvant chemotherapy after the completion of neoadjuvant chemotherapy; HR, Hazard ratio; CI, Confidence interval; *, P value for P_trend

^a Adjusted for age, type, grade, stage, upper abdominal surgery, bowel resection, lymphadenectomy, residual disease, postoperative complication, cycle of neoadjuvant chemotherapy and TTC (included as a quartile categorical variable)

^b Adjusted for age, type, grade, stage, upper abdominal surgery, bowel resection, lymphadenectomy, residual disease, postoperative complication, cycle of neoadjuvant chemotherapy and TTC (included as a continuous variable)

^c Adjusted for age, type, grade, stage, upper abdominal surgery, bowel resection, lymphadenectomy, residual disease, postoperative complication and cycle of neoadjuvant chemotherapy