Table 2.
Survival estimates of recurrence and mortality according to body mass index, waist circumference, and body fat percentage in 1099 patients with incident invasive breast cancer in the Malmö Diet and Cancer Study
| Endpoint | Body composition | No. of patients | Events | Unadjusted HR (95%CI) | Adjusted HRa (95%CI) |
|---|---|---|---|---|---|
| Body mass index | |||||
| Recurrence | Healthy weight | 556 | 129 | (ref) | (ref) |
| Overweight | 384 | 92 | 1.17 (0.89–1.54) | 1.23 (0.86–1.76) | |
| Obesity | 159 | 42 | 1.39 (0.98–1.99) | 1.56 (1.00–2.46) | |
| Mortality | Healthy weight | 556 | 166 | (ref) | (ref) |
| Overweight | 384 | 160 | 1.57 (1.26–1.96) | 1.18 (0.88–1.59) | |
| Obesity | 159 | 72 | 1.73 (1.31–2.29) | 1.51 (1.05–2.18) | |
| Waist circumference | |||||
| Recurrence | Healthy weight | 723 | 166 | (ref) | (ref) |
| Overweight | 119 | 33 | 1.34 (0.92–1.95) | 1.18 (0.73–1.90) | |
| Obesity | 223 | 59 | 1.35 (1.01–1.83) | 1.46 (1.00–2.13) | |
| Mortality | Healthy weight | 723 | 229 | (ref) | (ref) |
| Overweight | 119 | 45 | 1.26 (0.92–1.74) | 1.03 (0.67–1.58) | |
| Obesity | 223 | 113 | 1.71 (1.36–2.15) | 1.45 (1.07–1.96) | |
| Body fat percentage | |||||
| Recurrence | Healthy weight | 109 | 31 | (ref) | (ref) |
| Overweight | 476 | 101 | 0.96 (0.58–1.59) | 0.99 (0.53–1.85) | |
| Obesity | 514 | 131 | 1.25 (0.76–2.04) | 1.41 (1.02–1.98) | |
| Mortality | Healthy weight | 109 | 31 | (ref) | (ref) |
| Overweight | 476 | 151 | 1.39 (0.86–2.24) | 1.25 (0.71–2.20) | |
| Obesity | 514 | 216 | 1.97 (1.23–3.14) | 1.30 (0.74–2.27) | |
aAge, histological grade, tumor size, nodal status, estrogen-receptor status, surgery, planned adjuvant radio-, chemo-, and endocrine therapy
bHR Hazard ratio, CI Confidence interval